http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-875348-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba090c867801ab7bccb082f1b694ad25 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-38 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-38 |
| filingDate | 1960-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1961-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-875348-A |
| titleOfInvention | Improvements in or relating to trifluormethyl substituted phenoxazines |
| abstract | The invention comprises compounds of the formula <FORM:0875348/IV (b)/1> wherein R is hydrogen or methyl and Z is a substituted or unsubstituted heterocyclic amino group having up to 12 carbon atoms, and acid addition salts thereof, and the preparation thereof by building up the side chain by various condensations, for example, by alkylating a trifluoromethyl-phenoxazine with a reactive heterocyclic amino-alkyl ester and, when the formed 10-(heterocyclicaminoalkyl)-trifluoromethyl-phenoxazine derivative has a piperazinyl residue containing an N-protective group, removing said group and, if desired, further N-alkylating the product and, if desired, converting any product into its acid addition salts. The products are sedatives, tranquilizers and anti-emetics. 10 - [31 - (N-Carbethoxypiperazinyl)-propyl]-2-trifluoromethyl-phenoxazine is prepared by condensing 2-trifluoromethyl-phenoxazine with N-carbethoxy-N1-(3-chloropropyl)-piperazine. 10 - [31-(N-b -chloroethylpiperazinyl) -propyl]-2-trifluoromethyl-phenoxazine dihydrochloride is prepared by treating the corresponding hydroxy-compound with thionyl chloride. Phenylcarbonate of 10-[31-(N-hydroxyethylpiperazinyl) -propyl]-2-trifluoromethyl-phenoxazine is prepared by the action of phenylchlorocarbonate. 1 - (p-Nitrophenethyl)-4-[3-(2-trifluoromethyl-10-phenoxazinyl) -propyl]-piperazine is prepared by reacting 10 - (31-piperazinyl-propyl)-2-trifluoromethyl-phenoxazine with p-nitrophenethyl bromide. 3-Trifluoromethyl-phenoxazine is prepared by reacting N-benzyl-o-amino-phenol and 4-chloro-3-nitrobenzo-trifluoride and debenzylating the product.ALSO:Pharmaceutical compositions containing compounds of the formula <FORM:0875348/VI/1> (wherein R is hydrogen or methyl and Z is a substituted or unsubstituted heterocyclic amino radical having up to 12 carbon atoms) or acid addition salts thereof, with a carrier, may be in the form of capsules, tablets, suspensions and solutions for oral or parenteral use. Acid addition salts may be those with maleic, succinic, methanesulphonic, ethanedisulphonic, tartaric, salicylic, citric and theophylline acetic acids and 8-halotheophyllines and hydrochloric, sulphuric and phosphoric acids. |
| priorityDate | 1959-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.