http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-866446-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56666880a5e2b7703e98a4f9b2d9daf6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 |
| filingDate | 1959-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1961-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-866446-A |
| titleOfInvention | Improvements in or relating to estratriene derivatives |
| abstract | The invention comprises compounds of the general formula: <FORM:0866446/IV (b)/1> wherein X is halogen and Z is a carbonyl or hydroxymethylene radical or an alkanoyloxymethylene radical containing not more than 8 carbon atoms, and 16b ,17b -oxido-1,3,5(10)-estratriene. The compounds of the above general formula, where Z represents the carbonyl radical and X represents chlorine, bromine or iodine are prepared by treating a 1,3,5(10),16-estratetraen-17-ol-alkonoate with the required halogen in an inert solvent such as carbon tetrachloride, or with the required halogenating agent such as N-bromo- or N-iodo-succinimide. The corresponding 16-fluoro compounds are prepared by treating the 16-iodo compounds prepared as above with silver fluoride. The compounds of the above general formula in which Z represents a hydroxymethylene radical are prepared by treating the corresponding 17-ones with a reducing agent such as lithium aluminium hydride or sodium borohydride. Subsequent esterification forms the compounds in which Z represents the alkanoyloxymethylene radical. The processes outlined above form a mixture of the 16a and 16b -isomers in which usually one isomer predominates and which may be separated by crystallisation. 16b -Iodo (and chloro)-1,3,5 (10)-estratriene-17-one may also be prepared by treating the corresponding 16a -iodo (and chloro) compounds with a lithium halide. Detailed examples are given. 1,3,5(10),16-Estratetraen-17-ol acetate is prepared by reacting 1,3,5(10)-estratrien-17-one with isopropenyl acetate. |
| priorityDate | 1958-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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