http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-864678-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dc2f7134efa50484bb359fda73782848 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 1958-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1961-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-864678-A |
| titleOfInvention | Pyrazolo (3,4)ªÈ-triazine derivatives |
| abstract | The invention comprises pyrazolo [3, 4-d] v-triazines of the general formula: <FORM:0864678/IV (b)/1> (wherein Ar represents an aryl residue), tautomeric forms thereof, N-substitution products of the latter wherein the tautomerizing hydrogen atom is replaced by a group R- or <FORM:0864678/IV (b)/2> (R, R1, R2 and R3 representing aliphatic hydrocarbon groups each containing not more than 4 carbon atoms and R3 containing at least 2 carbon atoms) and salts of these compounds (including alkali metal salts as well as acid addition salts), and the preparation thereof by treating a 5-unsubstituted 2-aryl-3-(unsubstituted amino)- pyrazole-4-carboxylic acid amide with a diazotizing agent, and, if desired, treating a resulting compound containing a tautomerizing hydrogen atom with a hydrohalic or sulphuric acid ester of an alcohol of the formula: <FORM:0864678/IV (b)/3> The products are useful as diuretics (see Group VI), or as intermediates for the preparation of other medicaments. 2- Aryl-3- aminopyrazole-4- carboxylic acid amides are obtainable by the process of Specification 854,632. Thus 2-p-chlorophenyl-3-amino-4-carbanylpyrazole is prepared by condensing p-chlorophenylhydrazine with ethoxymethylenemalonitrile and hydrolysing the resulting 2-p-chlorophenyl-3- amino-4- cyanopyrazole.ALSO:Pharmaceutical preparations having diuretic properties comprise, in admixture with a pharmaceutical carrier suitable for enteral or parenteral administration, a pyrazolo[3,4-d]v-triazine of the general formula <FORM:0864678/VI/1> (wherein Ar represents an aryl residue), or a tautomeric form thereof, or an N-substitution product of the latter wherein the tautomerizing hydrogen atom is replaced by a group R- or <FORM:0864678/VI/2> (R, R1, R2 and R3 representing aliphatic hydrocarbon groups each containing not more than 4 carbon atoms and R3 containing at least 2 carbon atoms), or a salt of any of these compounds (e.g. an alkali metal salt or an addition salt with an acid such as a hydrohalic acid, sulphuric, nitric, perchloric, phosphoric, formic, acetic, propionic, oxalic, succinic, malic, tartaric, citric, ascorbic, methane-, ethane- or hydroxyethane-sulphonic, benzoic, salicylic or p-aminosalicylic acid or a toluene- or naphthalene-sulphonic acid). The preparations may be in the form of tablets, dragees, solutions, suspensions or emulsions. Specification 854,632 is referred to. |
| priorityDate | 1957-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.