http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-864231-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_232361c9031a709144573276863c462b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 |
| filingDate | 1958-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_545750f6d9b4b0cda72cd74debc692ff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a207477183046acb818e6f8507228ec7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f8fb120d6295e4a57e3743bd7812ccf |
| publicationDate | 1961-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-864231-A |
| titleOfInvention | Improvements in or relating to the preparation of steroids |
| abstract | The invention comprises compounds of the formula: <FORM:0864231/IV (b)/1> wherein R is hydrogen or acyl, and their preparation by oxidation of compounds of the formula: <FORM:0864231/IV (b)/2> wherein R is as above and X is the group -NR1R2 (R1 is an aliphatic, aralkyl or aryl group and R2 is an aliphatic or aralkyl group, or R1 and R2 together with the N atom form a heterocyclic ring, e.g. piperidino or morpholino) or the group -OR3 where R3 is an acyl radical, the above compounds being in turn prepared by reacting the corresponding 22-al compounds with an amine R1NHR2 or with an enol-acylating agent, e.g. acetic anhydride in the presence of an alkali metal acetate or a sulphonic acid. The 22-als are formed by oxidation, preferably ozonolysis, of neoergosterol or an ester thereof. Oxidation of the 22-enamines is effected (a) with a chromium trioxide-tertiary amine complex, (b) with an alkali metal dichromate in a liquid aliphatic carboxilic acid, or (c) with ozone, followed by reduction of the ozonide with zinc and acetic acid or by catalytic hydrogenation; the 22-enol acylates are oxidised by method of (c). Examples detail the preparation of 3b -hydroxy -19-nor pregna-5,7,9(10)-trien-20a -aldehyde, its 3-acetate and 20-enol acetate. 3b -hydroxy-20-piperidino methylene-19-norprenga-5,7, 9(10)-triene its 3- acetate, 3b -acetoxy-19-norpregna-5,7,9(10)-trien-20-one and the 3b -hydroxy analogue. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6525039-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9850412-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9850414-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6693207-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6818636-B2 |
| priorityDate | 1958-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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