http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-863662-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c902faf6ae746c51fc8010672fc22894 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 |
| filingDate | 1959-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1961-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-863662-A |
| titleOfInvention | Improvements in or relating to steroids and the manufacture thereof |
| abstract | The invention comprises compounds having the formula: <FORM:0863662/IV (b)/1> <FORM:0863662/IV (b)/2> wherein Y is methylene, b -hydroxy-methylene or carbonyl in formulae A and C, and methylene or b -hydroxymethylene in formula B and a process for the preparation thereof which comprises reacting a 3b , 17b -diacyloxy-17a -methyl-5-androsten-7-one with a methyl Grignard reagent to produce a 3b , 7, 17b -trihydroxy-7, 17a -dimethyl-5-androstene which is the oxidised e.g. by an Oppenauer oxidation to produce a 7, 17a -dimethyl-17b -hydroxy-4, 6-androstadien-3-one; this compound can be hydrogenated to produce a 7b , 17a -dimethyltestosterone or an 11-hydroxy group when present oxidised to obtain an 11-keto compound. Illustrative products of the invention are 7, 17a -dimethyl-17b -hydroxy- 4, 6-androstadien-3-one, 7, 17a -dimethyl-11b , 17b -dihydroxy-4, 6-androstadiene-3-one, 7, 17a -dimethyl-17b -hydroxy-4, 6-androstadiene-3 11-dione, 3, 7, 17b -trihydroxy-7, 17a -dimethyl-5-androstene and 3b , 7, 11b , 17b -tetrahydroxy-7, 17a -dimethyl-5-androstene. Specification 863,661 is referred to.ALSO:Pharmaceutical compositions comprise compounds having the formul <FORM:0863662/VI/1> <FORM:0863662/VI/2> <FORM:0863662/VI/3> wherein Y is methylene, b -hydroxy-methylene or carbonyl in formul A and C and methylene or b -hydroxymethylene in formula B, together with a liquid or solid pharmaceutical carrier in which the compound is dissolved, dispersed or suspended. Such compositions may be in the form of tablets, powders, capsules, pills, solutions, emulsions, suspensions, syrups and elixirs and may optionally comprise co-acting compounds. Specification 863,661 is referred to. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3264301-A |
| priorityDate | 1958-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID458393818 http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID457814461 |
Total number of triples: 15.