http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-861351-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c81932f7d567fb182b45fe6b92d10b6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L19-19 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L19-18 |
| filingDate | 1958-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1961-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-861351-A |
| titleOfInvention | Antibiotic compositions and methods of preparing them |
| abstract | Therapeutic compositions comprise a homogeneous admixture of a proteolytic enzyme and an antibiotic. The enzyme may be chymotrypsin, streptokinase, or preferably trypsin and especially the highly-purified forms of these. Examples given of antibiotics which are compatible with trypsin are, streptomycin, the penicillins, chloramphenicol, erythromycin, tetracycline, chlortetracycline, oxytetracycline and salts thereof. The compositions may be in forms suitable for oral, buccal, or parenteral administration, for example as tablets, enteric coated tablets, capsules, injectable solutions and suspensions, together with compatible pharmaceutical excipients. The antibiotics may be present in their usual dosage ranges whereas the amount of enzyme may be varied, depending on the particular pharmaceutical form. For example, a buccally administrable form may contain per therapeutic dose of antibiotic 1 to 10 (preferably 5) mg. of trypsin, enteric forms 10 to 40 (preferably 20) mg., a parenteral injection 2.5 to 10 (preferably 5) mg. Aqueous compositions may also contain a substance which protects the enzyme from self-digestion, for example, gelatine, the ratio of gelatine to trypsin being from 3 : 1 to 10 : 1 by weight. Preparations for injection may also be prepared in two separate portions, for example, lyophilized trypsin and a liquid preparation containing the antibiotic and other ingredients, or as a lyophilized preparation which gives an injectable solution on addition of water. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106758670-A |
| priorityDate | 1957-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.