http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-855167-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d1a6faffc381ea8994c77336c1d3c9a0 |
| filingDate | 1958-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1960-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-855167-A |
| titleOfInvention | Purification of aqueous solutions of streptomycin and/or dihydrostreptomycin |
| abstract | Streptidine is removed from aqueous solutions of streptomycin and/or dihydrostreptomycin containing it, by adding to said aqueous solutions a 2,6-dihalogenated -4-nitrophenol at a pH of 5,8 to 10,5 and especially 6,5 to 7,5 and removing the resulting precipitate by e.g. filtration. The 2,6-dihalogenated-4-nitrophenol is preferably used in excess and may be 1,000% equivalent based on the streptidine content of the antibiotic solution. The excess precipitant is removed from the streptidine-free antibiotic solution by acidifying to pH at least 2,5 to precipitate the 2,6-dihalogenated 4-nitro-phenol and then passing the filtrate over charcoal at pH 7,0. Adjustment of pH in the streptidine precipitation step is by means of alkali metal and alkaline earth metal oxides, hydroxides, carbonates or bicarbonates or by organic nitrogen bases e.g. triethylamine. The time to effect precipitation is dependant upon the quantity of streptidine to be precipitated and the principal antibiotic and is generally 4 to 200 hours. Specified precipitants are 2,6-dibromo-4-nitrophenol; 2,6-dichloro-4-nitro-phenol; 2,6-diiodo-4-nitrophenol and 2,6-difuoro-4-nitrophenol. |
| priorityDate | 1957-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.