http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-854464-A
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7780e9d205ef3d354fe484bbc65b155c |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 |
filingDate | 1957-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 1960-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | GB-854464-A |
titleOfInvention | Cyclopentanophenanthrene derivatives and process for the preparation thereof |
abstract | The invention comprises compounds of the formula : <FORM:0854464/IV(b)/1> wherein R is an aralkyl group, R1 is b -hydroxy or keto, and R2 is hydrogen or an acyl group, preferably from a hydrocarbon carboxylic acid of less than 12 carbon atoms, together with (a) a process for the preparation of compounds of the above formula wherein R is an alkyl or aralkyl group, R1 is b -hydroxy or keto and R2 is hydrogen by adding the corresponding D 4-pregnenes to a nutrient medium containing a culture of Corynebacterium simplex, maintaining the mixture under growth conditions while stirring continuously for 24 hrs at a temperature slightly above room temperature and isolating the resulting D 1,4-steroid, and (b) a process for the preparation of compounds of the above formula wherein R2 is hydrogen, R1 is b -hydroxy or keto and R is alkyl or aralkyl with the proviso that when R is alkyl R1 is keto, by catalytic hydrogenation the 21-ester of the corresponding D 4-pregnene, treatment of the resulting allopregnane with approximately 2 mols of bromine, dehydrobromination of the resulting 2,4-dibromo allopregnane with a tertiary organic base and saponification of the 21-ester group. Detailed examples illustrate the preparation of 2-methyl-D 1,4- pregnadiene-17a , 21-diol-3, 11, 20-trione by processes "a" and "b" and of its 2-ethyl-, 2-propyl and 2-benzyl-anologues and 2-benzyl-D 1,4 pregnadiene-11b , 17a , 21-diol-3, 20-dione by process "b". Reference has been directed by the Comptroller to Specification 794,485. |
priorityDate | 1956-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.