http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-853592-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H13-12 |
| filingDate | 1957-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1960-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-853592-A |
| titleOfInvention | Derivatives of novobiocin |
| abstract | The invention comprises methyl 3-carbamyl-4-methylnovobioside and 3-carbamyl-4-methylnovobiose having respectively the formulae : <FORM:0853592/IV(b)/1> and the preparation thereof by reacting novobiocin with a non-oxidizing mineral acid in methanolic solution to produce the former compound with the optional further step of reacting the product with a dilute aqueous nonoxidizing mineral acid solution to produce the latter compound. A suitable non-oxidizing mineral acid is hydrochloric acid. The invention also includes (a) a process for the preparation of 3-carbamyl-4-methylnovobiose diethyl mercaptal of the formula : <FORM:0853592/IV(b)/2> by reacting methyl 3-carbamyl-4-methylnovobioside with ethyl mercaptam in the presence of hydrogen chloride with optional further items of reacting the product with Raney nickel to produce 3-carbamyl-4-methyl-1-deoxynovobiose of the formula: <FORM:0853592/IV(b)/3> hydrolysing this compound with sodium hydroxide to form 4-methyl-1-deoxynovobiose of the formula: <FORM:0853592/IV(b)/4> and treating this compound with carbamyl chloride to form 3-carbamyl-4-methyl-1-deoxynovobiose and 2-carbamyl-4-methyl-1-deoxynovobiose ; and (b) a process for the preparation of methyl 4-methylnovobioside of the formula: <FORM:0853592/IV(b)/5> by heating methyl 3-carbamyl-4-methylnovobioside with sodium hydroxide with the optional further step of reacting the product with carbamyl chloride to form methyl 3-carbamyl-4-methyl-novobioside of the formula given above and methyl 2-carbamyl-4-methylnovobioside. Detailed examples are given. Specifications 821,819 and 821,820 are referred to. |
| priorityDate | 1956-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.