http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-851886-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba090c867801ab7bccb082f1b694ad25 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D279-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D279-18 |
| filingDate | 1958-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1960-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-851886-A |
| titleOfInvention | Substituted phenothiazinyl trifluoromethyl sulfones |
| abstract | The invention comprises compounds of the class consisting of a free base and its non-toxic salts, the free base having the formula : <FORM:0851886/IV(b)/1> in which A is an alkylene chain having 2-6 carbon atoms and separating the nitrogens to which it is attached by at least 2 carbon atoms; and R1 and R2 represent hydrogen or alkyl having from 1-6 carbon atoms and, when taken together with the nitrogen to which they are attached form a five to six membered heretocyclic ring. Preferred compounds have the formula : <FORM:0851886/IV(b)/2> in which Z is dimethylamino, piperazinyl, alkyl piperazinyl in which the alkyl moiety has 1-6 carbon atoms, alkanoyloxy-alkylene piperazinyl in which the alkanoyl moiety has 1-6 carbon atoms and the alkylene moiety has 2-6 carbon atoms, hydroxyalkyleneoxy-alkylene piperazinyl in which each of the alkylene moieties has from 2-6 carbon atoms or hydroxyalkylene piperazinyl in which the alkylene moiety has 2-6 carbon atoms. The compounds are obtained by condensing a phenothiazinyl trifluoromethyl sulphone with a reactive tertiary aminoalkyl ester having the desired dialkylaminoalkyl group e.g. a dialkylaminoalkyl chloride or bromide ; illustrative products of the invention are 2-trifluoromethylsulphonylphenothiazine's bearing in 10-position 31-dimethylaminopropyl, 31-(411-methyl-111-piperazinyl), 31-(N-b -hydroxylethylpiperazinyl)-propyl, 31(N-b -acetoxyethylpiperazinyl)-propyl, 31-(N-hydroxyethoxyethylpiperazinyl)-propyl, and 21-methyl-31-(411-methyl -11-piperazinyl)-propyl. Specification 851,887 is referred to. |
| priorityDate | 1957-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.