http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-851741-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e737b999245afb461a9a9e552e8f3a1e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 |
| filingDate | 1957-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51d463c53347e6e8067b94b8713cac7f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb9c75dfdcc0f27064b556a0c693e30b |
| publicationDate | 1960-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-851741-A |
| titleOfInvention | Improvements in or relating to the preparation of 6-methyl steroid compounds |
| abstract | The invention comprises steroid compounds of the general formulae <FORM:0851741/IV(b)/1> <FORM:0851741/IV(b)/2> wherein R represents an acyl group containing up to 10 carbon atoms, and a process for the preparation of 3b -hydroxy-6-methyl-25D-spirost -5-ene and the corresponding 3b -acyloxy compound by reacting 3b -acyloxy-25D-spirost-5-ene with a hypobromous acid or with N-bromoacetamide and perchloric acid to form a 3b -acyloxy-5a -bromo-25D- spirostan-6b -ol, oxidising this compound to form a 3b -acyloxy-5a -bromo-25D-spirostan-6-one, replacing the bromine atom in this compound by hydrogen to form a 3b -acyloxy-5a :25D-spirostan-6-one, reacting this compound with a methyl magnesium halide and reacylating the product to form a 3b -acyloxy-6a -methyl-5a :25D-spirostan-6b -ol, and dehydrating this compound with thionyl chloride in a tertiary base such as pyridine to form the desired 3b -acyloxy compound which may be hydrolysed to the corresponding 3b -hydroxy compound. One detailed example is given illustrating the above process with particular reference to the 3b -acetoxy starting compound, intermediate products and final product which is then hydrolysed as above. Specifications 841,870 and 851,742 are referred to. |
| priorityDate | 1957-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.