http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-850418-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_73ee0bacab5a7576a6a3244747f6ea99 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D261-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D261-06 |
| filingDate | 1958-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc4e346e5c0f34124e5b4c09dae94714 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73825bdb36ce1a37403bf65a6ebcfe7a |
| publicationDate | 1960-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-850418-A |
| titleOfInvention | Process for the manufacture of nitrogen-containing heterocyclic compounds |
| abstract | Nitrogen containing heterocyclic compounds (probably isoxazole derivatives) are prepared by reacting a nitrone of the formula: <FORM:0850418/IV(b)/1> wherein R and R1 represent hydrogen, alkyl, cycloalkyl, aryl or aralkyl, R11 represents alkyl, cycloalkyl, aryl or aralkyl, or R and R1 or R and R11 may be joined together to form a group of non-metallic atoms, with an unsaturated compound of the formula: <FORM:0850418/IV(b)/2> wherein A1, A2, A3 and A4 represent hydrogen, cyano, carbalkoxy or substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl or aralkyl (including phenoxyethyl), or A1 and A2, A3 and A4 or A2 and A4 may be joined together to form groups of non-metallic atoms. The nitrone may be formed in situ during the reaction, using as starting materials a ketone or aldehyde of the formula R,CO,R1, a hydroxylamine of the formula R11,NHOH and the previously defined unsaturated compound. Specified unsaturated compounds are ethylene, propylene, cyclohexene, acrylonitrile, ethylacrylate, allyl acetone, menhene, citronellal, tetraphenylcyclopentadienone, cyclopentadiene, butadiene, isoprene, 2 : 3-dimethylbutadiene-1 : 3, 1 : 4-diphenylbutadiene, 1-vinylnaphthalene, a -phellandrene, carotene, chloroprene, diethylmuconate, coumalin, alloocimine, unsaturated fatty acid glycerides, ethyloleate, tung oil, p dehydrated castor oil, fatty acid methyl ester, crotononitrile and dimers thereof. Specified nitrones are 2 : 3 : 4 : 5-tetrahydropyridine-N-oxide, 4 : 5 : 5-trimethyl\se1-pyrroline-N-oxide, b -benzyl-isobenzaldoxime, b -phenylisobenzaldoxime, b -phenyliso-para - methoxybenzaldoxime, b -phenyliso-meta-nitrobenzaldoxime, N-ethylnitrone, N-methylnitrone, N : C-dimethylnitrone, cyclohexylidine, cyclohexylamine-N-oxide, 3 : 4-dihydroisoquinoline-N -oxide, oligomers of the foregoing compounds and salts thereof, e.g. with quinol. Nitrones of the formula: <FORM:0850418/IV(b)/3> are prepared (1) by oxidizing a compound of the formula: <FORM:0850418/IV(b)/4> with an oxidizing agent such as mercuric oxide, cupric acetate or benzoquinone; (2) by oxidation of an appropriate Schiffs' base with hydrogen peroxide; or (3) by condensing an aldehydle or ketone of the formula R,CO,R with a hydroxylamine of the formula R11,NHOH. Using benzoquinone as an oxidizing agent, a quinol salt of the nitrone may be isolated. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2137619-A |
| priorityDate | 1958-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.