http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-843773-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5528d8d64c9da539b3fa8028a22bede6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 |
| filingDate | 1956-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1960-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-843773-A |
| titleOfInvention | Synthesis of steroids |
| abstract | The invention comprises a steroid of the general formula: <FORM:0843773/IV(b)/1> wherein the 1,2 and 6,7-positions are saturated or double bonded, wherein individually R is hydrogen and R1 is hydroxy or together R and R1 are keto or ketalised keto, wherein individually R1 1 is hydrogen and R1 1 1 is hydroxy or together R1 1 and R1 1 1 are keto and wherein X is halogen, Y is hydrogen, hydroxy or acyloxy, and Z is hydrogen or a -hydroxy, a compound of the general formula: <FORM:0843773/IV(b)/2> wherein X1 is chloro or fluoro, the corresponding 4-bromo compound, and a process for preparing a 12a -halo-11b -hydroxy steroid of the d 4-pregnene series, which comprises reacting the corresponding 12a -halo-11b -hydroxy steroid of the pregnane series, saturated in 1,2; 4,5; and 6,7 positions with bromine, and dehydrobrominating the 4-brominated intermediate formed thereby. Such compounds may be prepared by (a) converting a d 1 1-pregnane to the corresponding 12a -bromo-11b -hydroxy steroid; (b) converting the latter compound to the corresponding 11b , 12b -epoxy derivative which is converted to a 12a -fluoro, chloro derivative; (c) converting the 12a -halo-11b -hydroxy compound to a 4-bromo or 2, 4-dibromo compound and dehydrobrominating; (d) optionally oxidising the 11-hydroxy group to an 11-keto group. Illustrative products of the invention are 12a -chloro-11b -hydroxyprogesterone, 12a -fluoro-11b -hydroxyprogesterone, 12a -chloro-11-ketoprogesterone and 12a -fluoro-11-ketoprogesterone. Other examples are mentioned. Reference has been directed by the Comptroller to Specification 779,989. |
| priorityDate | 1955-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.