http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-842651-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_015deedadcb927cbda13c58fd157e321 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-03 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-03 |
| filingDate | 1957-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b9ca1275a3b75337f063e3619fe4364 |
| publicationDate | 1960-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-842651-A |
| titleOfInvention | Novel acetylene compounds and process of preparing same |
| abstract | The invention comprises compounds of the formula: <FORM:0842651/IV(b)/1> wherein m and n represent the same or a different integer greater than 1 and the sum of which is at least 4; R1, R2, R3 and R4 represent the same or a different alkyl, alkenyl, aryl, aralkyl, cycloalkyl, cycloalkenyl or heterocyclic group or a group wherein R1 and R2, and R3 and R4, ar joined so that the nitrogen is part of a heterocyclic group (e.g. pyrrolidino-, piperidino- or morpholino-); and acid addition salts and quaternary ammonium salts thereof. The compounds are prepared (1) by reaching at an elevated temperature a compound to the formula: <FORM:0842651/IV(b)/2> (where X is halogen) with a compound of the formula: <FORM:0842651/IV(b)/3> (where Y is a reactive metal); and (2) by reacting a compound of the formula: <FORM:0842651/IV(b)/4> with a compound of the formula: <FORM:0842651/IV(b)/5> (where X is halogen) to produce compound of the formula: <FORM:0842651/IV(b)/6> and reacting the latter in the form of a reactive metal salt at an elevated temperature with a compound of the formula: <FORM:0842651/IV(b)/7> (where X is halogen). Acid addition salts may be obtained by subsequent treatment with, e.g., hydrohalic, sulphuric, formic or citric acids. Quaternary salts are obtained by subsequent treatment with alkyl and aralkyl esters of mineral and organic acids, e.g. methyl chloride, ethyl bromide and methyl sulphate. The compounds are used for lowering blood pressure. They may be reduced to the corresponding olefin derivatives and the latter may be either polymerized or hydrolyzed to the corresponding ketones and then reduced with sodium borohydride to give the corresponding alcohols. Reactive metal salts of the formula: <FORM:0842651/IV(b)/8> (where Y is a reactive metal, e.g. Li, Na or K) are prepared by reacting aminoalkynes of the formula: <FORM:0842651/IV(b)/9> with an alkali metal amide or hydride. Specification 750,346 is referred to.ALSO:A pharmaceutical composition comprises as the active ingredient a bis-aminoacetylene of the formula: wherein m and n represent the same or a different integer greater than 1 and the sum of which is at least 4; R1, R2, R3 and R4 represent the same or a different alkyl, alkenyl, aryl, aralkyl, cycloalkyl, cycloalkenyl or heterocyclic group or a group wherein R1 and R2, and R3 and R4, are joined so that the nitrogen is part of a heterocyclic group, or aid addition or graternary ammonium salts thereof, together with a suitable pharmaceutical carrier. The composition may be in the form of solutions, isotaric solutions, suspensions, powders, tablets or capsules. Specification 750,346 is referred to. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9215551-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3201467-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-1172925-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5508311-A |
| priorityDate | 1957-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.