http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-839908-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8a0e90292f2ba83d7878baca3838b8a2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 |
| filingDate | 1957-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_163e2396e1072fbe894907aeffb32c1f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07b28c0c7d747cd9e8daa54c87cc3479 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55c824af7ae01c7c6bd13dc804e45de2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7bb73b843a098aa7ad675a2c82e60072 |
| publicationDate | 1960-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-839908-A |
| titleOfInvention | 4,17ª‡-dihydroxy progesterone and its esters and the preparation thereof |
| abstract | The invention comprises 4,17a -dihydroxy-progesterones and p esters thereof having the general formula <FORM:0839908/IV (b)/1> wherein R and R1 are the same or different and represent hydrogen or an acyl group derived from an aliphatic carboxylic acid containing less than 9 carbon atoms, and the preparation thereof by reacting a 17a -acyloxy progesterone derived from an aliphatic carboxylic acid containing less than 9 carbon atoms with hydrogen peroxide and an alkali to form the corresponding 4,5 - epoxy - 17a - acyloxy - progesterone in the form of a mixture of the 4,5b - and 4,5a -isomers, reacting the 4,5-epoxy compounds with a mixture of glacial acetic acid and concentrated sulphuric acid to form 4-hydroxy-17a -acyloxy-progesterone (which may exist in the ketonic form, i.e. 3,4,20-triketo-17a -acyloxy-pregnane), and hydrolysing this compound to form 4,17a -dihydroxy-progesterone. The esters may be prepared by esterifying the 4,17a -dihydroxy-progesterone or 4 - hydroxy - 17a - acyloxy-progesterone, thus 4,17a - dihydroxy - progesterone may be selectively acylated in the 4-position with the required anhydride in the presence of pyridine. The ester groups may be derived from formic, acetic, propionic, butyric, valerionic, caproic, enanthic, caprylic, b -cyclopentanepropionic and cyclohexaneacetic acids. In the examples 4,17a -dihydroxyprogesterone and the 4-acetate, 4,17-diacetate and 17-caproate thereof are prepared. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-RE39862-E http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6710039-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0142275-A1 |
| priorityDate | 1957-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.