http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-837447-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4acae202b6a15394281949545e70d2f6 |
| filingDate | 1956-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1960-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-837447-A |
| titleOfInvention | Improvements in or relating to ª†-glutamyl peptides |
| abstract | g -L-glutamyl peptides of the formula <FORM:0837447/IV (b)/1> where n is 0-8, and R1 is H or an alkyl, aralkyl, aryl or heterocyclic radical which may contain a hydroxy radical or a group -S-(CH2)n1-H (where n1 is 1-3), are prepared by reacting, in the presence of dicyclohexyl carbodiimide, a solution in an inert solvent of N-trityl-L-glutamic acid or a salt thereof with a tertiary organic base, with an amino acid ester of formula H2NCH(COOR).(CH2)n - R1 where R is an alkyl radical of up to 8 carbon atoms, by leaving to stand or heating such solution at from 0 DEG C. to the reflux temperature of the solvent, removing any excess of carbodiimide, saponifying by alkali treatment, isolating the resulting N-trityl peptide and detritylating. Preferred features are the use of the triethylamine salt of N-trityl-L-glutamic acid, the use of methylene chloride as solvent and ambient temperature, the removal of excess carbodiimide with acetic acid, saponification with ethanolic caustic soda, and detritylation by means of aqueous or ethanolic acetic acid. In examples, the amino acid ester is ethyl L-tyrosinate, ethyl L-leucinate, L-methionine methyl ester, and ethyl glycinate. Specifications 813,927, 826,925, 837,446 and 837,450 are referred to. |
| priorityDate | 1955-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.