http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-835700-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d629f98a51b15993f56f9e04fdea237f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P33-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P33-00 |
| filingDate | 1956-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1960-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-835700-A |
| titleOfInvention | Improvements relating to 1, 4-pregnadienes and the preparation thereof |
| abstract | The invention comprises cyclopentanophenanthrene compounds of the general formula <FORM:0835700/IV (b)/1> wherein X represents H2, <FORM:0835700/IV (b)/2> R represents hydrogen or an acyl group, preferably formyl or an alkanoyl group having up to 5 carbon atoms, and one of Y and Z represents a hydroxy group and the other represents hydrogen, and a process for the preparation of compounds of the above general formula wherein X, Y and Z have the above significance and R represents hydrogen or the lower alkanoyl group by subjecting the corresponding compound in which X and Y are hydrogen to the oxygenating substances produced by growing the micro-organism Heliocostylum piriforme under aerobic conditions. The above process may be modified in that the compounds prepared in which R represents hydrogen is subsequently esterified to form the 21-carboxylic ester e.g., the benzoic, salicylic, p-aminobenzoic, anisic, veratric or other aromatic ester. The alkanoyl group may be derived from acetic, propionic or isovaleric acid. Compounds of the above general formula having an 11a - or 11b -hydroxy group may be oxidized, e.g. with chromic acid in pyridine, to form the corresponding 11-keto compounds. In the examples, 1,4-pregnadiene-14,17a ,21-triol-3,20-dione and 1,4-pregnadiene-8,17a ,21-triol-3,20-dione and the corresponding 11-keto and 11b -hydroxy-substituted compounds and the 21-acetates of all these compounds are prepared. |
| priorityDate | 1955-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.