http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-835474-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_73ee0bacab5a7576a6a3244747f6ea99 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-233 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-233 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 |
| filingDate | 1957-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8163fa650de450b6a9d8920c4054e85f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_419a95a7ead520f49f64ac60958f98cc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3918ac3245360c86b933caa8081a7832 |
| publicationDate | 1960-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-835474-A |
| titleOfInvention | Pharmaceutical compositions comprising quinolone derivatives |
| abstract | 1 - Methyl - and 1 - ethyl - 7 - nitro - 4 - quinolone are prepared by reacting dimethyl or diethyl sulphate with 4-hydroxy-7-nitroquinoline in the presence of sodium hydroxide. 4 - Hydroxy - 7 - nitroquinoline is prepared by heating together 3-carboxy-4-hydroxy-7-nitroquinoline and benzophenone. 6 - Chloro - 1 - ethyl - 3 - methyl - 4 - quinolone and 6 - chloro - 1 - methyl - 4 - quinolone are obtained by reacting 6-chloro-4-hydroxy-3-methylquinoline and 6-chloro-4-hydroxyquinoline with a diethyl and dimethyl sulphate respectively. 1 - Ethyl - 3 - methyl - 6 - nitro - 4 - quinolone is prepared by heating together 4-hydroxy-3-methyl - 6 - nitroquinoline, anhydrous potassium carbonate, ethyl iodide and b -ethoxyethanol. Similarly, but using 6-chloro-4-hydroxy - 2,3 - dimethylquinoline there is obtained 6 - chloro - 1 - ethyl - 2,3 - dimethyl - 4 - quinoline and by using 4 - hydroxy - 2,3-dimethyl - 6 - nitro - quinoline and methyl iodide there results 1,2,3-trimethyl-6-nitro-4-quinoline. By using 4-hydroxy-6-nitroquinoline and di-ethyl sulphate, 1-ethyl-6-nitro-4-quinoline is obtained.ALSO:Pharmaceutical and veterinary compositions comprise non-toxic pharmaceutical excipients and one or more compounds of general formula <FORM:0835474/VI/1> wherein the benzene ring "A" bears one or more substituents which may be nitro-groups or halogen atoms, R is an alkyl or alkenyl radical having not more than 4 carbon atoms, R1 and R2 axis hydrogen or an alkyl radical of not more than 4 carbon atoms and may be the same or different. Specified compounds are the following 4-quinolones: 1-methyl-6-nitro and 1 : 3-dimethyl-6-nitro (both preferred), 1-methyl-7-nitro, 1-ethyl-7-nitro, 1-ethyl-3-methyl - 6 - nitro, 1 : 2 : 3 - trimethyl - 6 - nitro, 6 - chloro - 1 - ethyl - 2 : 3 - dimethyl, 6 - chloro - 1 - ethyl - 2 : 3 - dimethyl, 6 - chloro-1 - ethyl - 3 - methyl, 6 - chloro - 1 - methyl. Other known antibacterial agents, e.g. penicillins, sulphonamides, e.g. 2-paminobenzene-sulphonamido - 4 : 6 - dimethylpyrimidine, 1 : 6 - bis - p - chloro - phenyldiguanidohexane, furazolidone, chlortetracycline, oxytetracycline, hydrocortisone acetate. The compositions may be in forms suitable for oral, parenteral and external application, e.g. tablets, pills, dispersable powders and granules, syrups, solutions, dispersions, creams, ointments, finely-divided powders, or premixes with foodstuffs. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-3521264-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6541470-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7109338-B2 |
| priorityDate | 1957-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 72.