http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-833799-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4acae202b6a15394281949545e70d2f6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-38 |
| filingDate | 1957-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1960-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-833799-A |
| titleOfInvention | Thiocolchicine derivatives and their preparation |
| abstract | The invention comprises the lactam of 12,13,14 - trimethoxy - 9 - methylthio - 3a - amino - 4,8 - dihydro - 4,5 - 6,7 - dibenzo - D 4,6 - cycloheptadiene - 8a - carboxylic acid (I), the lactam of 12,13,14-trimethoxy-9-methylthio3a - amino - 4,5 - 6,7 - dibenzo - D 4,6 - cycloheptadiene-8-carboxylic acid (II), and their preparation from thiocolchicine by treatment with an alkali metal mercaptide in an anhydrous medium yielding (I), and subsequent aromatization by means of alkali to give (II). The 4,5 - 6,7 - dibenzo - D 4,6 - cycloheptadiene system is numbered as below <FORM:0833799/IV (b)/1> In examples: (1) thiocolchicine in anhydrous methanol is treated with sodium methylmercaptide at room temperature, chloroform added, the mixture washed, dried, concentrated and the residue in chloroform chromatographed on alumina, giving the methyl ester of colchicic acid, unchanged thiocolchicine and finally (I); (2) (I) is treated in ethanol with aqueous 10N NaOH, the mixture left for two days, acidified, and then extracted with chloroform yielding II. Specification 762,706 is referred to. |
| priorityDate | 1956-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.