http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-833546-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3395c5cb958d81965344886b0ca92581 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 |
| filingDate | 1957-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1960-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-833546-A |
| titleOfInvention | Improvements in or relating to steroid compounds |
| abstract | The invention comprises 4b ,17b -diacetoxyetiocholan - 3 - one, 21 - succinate of di - [D 16-pregnene - 21 - ol - 3,20 - dione], 3a - hydroxy-21 - acetoxy - D 16 - pregnene - 11,20 - dione, 3a ,17a - dihydroxy - 21 - formyloxy - pregnane-11,20 - dione and 3a ,17a - dihydroxy - 21-benzoyloxy - pregnane - 11,20 - dione, and the preparation of acyloxylated steroids by reacting a mono -, di - or poly - halogenated steroid with an alkali metal salt of a carboxylic acid in the presence of a solvent for the reactants consisting of or containing a major proportion of dimethylformamide. The reaction is preferably carried out in an atmosphere of an inert gas. The halogen atoms in the steroid reactants are preferably bromine atoms. The alkali metal salt of the carboxylic acid may be a sodium, potassium or lithium salt. Suitable steroid reactants are halogenated genins and their degradation products, sterols and their degradation products, bile acids and their degradation products, pregnanes, allopregnanes, etiocholanes, androstanes, 19-nor-steroid compounds, and derivatives of the aldosterone group of compounds containing a keto, hydroxy or acyloxy group in the 18-position. In the examples 3a ,17a -dihydroxy-21-acetoxy (and formyloxy and benzoyloxy)-pregnane - 11,20 - dione are prepared from 21 - bromo - 3a ,17a - dihydroxy - pregnane - 11,20 - dione; 21 - acetoxy - D 16 - pregnene - 3,20-dione is prepared from 21-bromo- D 16-pregnene-3,20-dione; the 21-succinate of di[D 16 - pregnene - 21 - ol - 3,20 - dione] is prepared from 21-bromo- D 16-pregnene-3,20-dione; 3a - hydroxy - 21 - acetoxy - D 16 - pregnene11,20-dione is prepared from 3a -hydroxy-21bromo - D 16 - pregnene - 11,20 - dione; 4 - bromo - 17a - hydroxy - 21 - acetoxy (and hexahydrobenzoyloxy) - pregnane - 3,11,20 - trione are prepared from 4,21-dibromo-17a hydroxy - pregnane - 3,11,20 - trione (the hexahydrobenzoate may then be dehydrobrominated to form the hexahydrobenzoate of cortisone); 4 - bromo - 17a - hydroxy - 21 - acetoxy - D 1 - pregnene - 3,11,20 - trione is prepared from 4,21-dibromo-17a -hydroxy- D 1pregnene-3,11,20-trione, and may then be debrominated with zinc and acetic acid to form 17a - hydroxy - 21 - acetoxy - D 1 - pregnene - 3,11,20-trione or dehydrobrominated to form the 21-acetate of D 1-dehydrocortisone; 4b ,17b -diacetoxy - ethiocholan - 3 - one is prepared from 4b - bromo - 17b - acetoxy - etiocholan - 3 - one; 3a ,12a ,21 - triacetoxy - 24,24 - diphenyl - D 20(22)23-choladiene is prepared from 3a ,12a diacetoxy - 21 - bromo - 24,24 - diphenyl - D 20(22)23 - choladiene, and 3a ,21 - diacetoxyD 16 - pregnen - 20 - one is prepared from 21bromo - 3a - acetoxy - D 16 - pregnen - 20 - one. Specifications 760,361, 760,362, 787,395, 828,601 and 832,245 are referred to. |
| priorityDate | 1956-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.