http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-826838-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1ba1a05a5be3ec8cc37ff3be3492b66a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 1957-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08f25ab6288d2833303e6f85f06440aa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49d2190165de77c94706f391d8c81ab2 |
| publicationDate | 1960-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-826838-A |
| titleOfInvention | Arylsulfonyl derivatives of bicyclic guanidines |
| abstract | The invention comprises compounds of the formula <FORM:0826838/IV (b)/1> wherein n is an integer from 2 to 4, m is an integer from 2 to 3 and Ar is a phenyl radical optionally substituted by alkyl, amino, nitro, acylamino, hydroxy or alkoxy groups, preferably in the para position; and their preparation by reacting the corresponding bicyclic guanidine with an aryl sulphonyl chloride in aqueous alkaline solution in the presence of a solvent such as diethyl ether. The preparation may also be carried out using pyridine as both solvent and acid-binding agent. Compounds in which Ar is an aminophenyl group are made by hydrolysis of the corresponding acylamino compounds. Examples describe the preparation of 1-p-toluenesulphonyl-, 1-p-acetylaminobenzenesulphonyl-, 1 - p - nitrobenzenesulphonyl- and (by hydrolysis) 1-p-aminobenzenesulphonyl-, 2 : 3 : 5 : 6 - tetrahydro - 1 - imidaz-(1 : 2-a)-imidazole; 1-p-toluenesulphonyl- and 1-p-acetylaminobenzenesulphonyl-, D 8-hexahydro-1 : 4 : 8-pyrimidazole and 1-p-toluenesulphonyl-, 1 - p - acetylaminobenzenesulphonyl- and (by hydrolysis) 1 - p - aminobenzenesulphonyl -, D 9 - 1 : 4 : 9 - triazabicyclo - (5 : 3 : 0) - decene. Specification 826,837 is referred to.ALSO:Bacteriostatic preparations for external use comprise sulphonyl derivatives of bicyclic guanidines of the formula <FORM:0826838/VI/1> wherein n is an integer from 2 to 4, m is an integer from 2 to 3 and Ar is a phenyl or alkyl-, amino-, nitro acylamino-, hydroxy- or alkoxy-substituted phenyl group (see Group IV (b)) and a carrier. A cream for external use comprises 1 - p - toluenesulphonyl - D 8 - hexahydro - 1 : 4 : 8 - pyrimidazole, yellow beeswax, wool fat, liquid paraffin and water. Specification 826,837, [Group IV (b)], is referred to. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0866793-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0866793-A1 |
| priorityDate | 1957-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.