http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-822966-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ea7da26cb077e35d67c7703ba5e49d7d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S516-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-185 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-185 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-24 |
| filingDate | 1957-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1959-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-822966-A |
| titleOfInvention | Manufacture of n,n-disubstituted amides of aryl acetic acids |
| abstract | The invention comprises N,N-disubstituted arylacetic acid amides of the general formula <FORM:0822966/IV (a)/1> (wherein R is an aryl group which may contain halogen, alkyl and alkoxy substituents, R1 and R2 are each an alkyl, aralkyl, alicyclic, heterocyclic or dialkylaminoalkyl group, and R3 is a dialkylamino, -N-morpholino, -N-piperidino, -N-piperazino, -N-pyrrolidino, <FORM:0822966/IV (a)/2> or <FORM:0822966/IV (a)/3> group) and the acid addition and quaternary ammonium salts of these compounds when amines (but excluding those compounds described and claimed in Specification 771,814), and the preparation thereof by reacting an amide of the formula R-CHR1-CO-R3 with a compound R2Y (wherein Y is a halogen) in substantially equimolecular proportions in the presence of a strongly basic condensing agent and, if desired, converting the products, when amines, into acid addition and quaternary ammonium salts. Advantageously, the condensation is carried out in an inert solvent such as benzene, toluene, xylene or dioxan, suitable condensing agents being, for example, sodium or potassium amide, phenyl sodium or sodium hydride. Examples describe the preparation of a - phenyl - a - (2 - thenyl) - g - dimethylaminobutyric acid diethylamide, a -benzyl-a -(2-morpholinoethyl) - phenanthryl - 31 - acetic acid diethylamide, a -benzyl-a -(2-morpholinoethyl) - naphthyl - 11 - acetic acid di - isopropylamide, a ,a - bis - (dimethylaminoethyl) - phenylacetic acid diethylamide dihydrochloride and a - benzyl - a - (2 - morpholinoethyl) - N - n - propyl - N - benzyl - phenylacetic acid amide; the following are listed, in some cases with physical constants: a - benzyl - a - (2-dimethylaminoethyl) - phenylacetic acid dimethylamide, a - benzyl - a - (2 - diethylamino-ethyl) - phenylacetic acid diethylamide, a -(3,3 - dimethylaminobutyl) - a - (21 - dimethylaminoethyl) - phenylacetic and diethylamide, a - (3,3 - dimethylbutyl) - a - (31 - diethylaminopropyl) - phenylacetic acid diethylamide, a - cyclohexyl - a - (2 - morpholinoethyl)-and (3 - diethylaminopropyl) - phenylacetic acid diethylamide, a ,a -bis-(2-dimethylaminoethyl) - phenylacetic acid diethylamide, a - (2 - diethylaminoethyl) - a - ethylphenylacetic acid di - isopropylamide, a - benzyl - a - diethylamino - phenylacetic acid diethylamide, a - diethylamino - a - (3 - diethylaminopropyl) - phenylacetic acid diethylamide, a -benzyl - a - (2 - diethylaminoethyl) - phenylacetic acid piperidide, a -benzyl-a -(2- morpholinoethyl) - phenylacetic acid piperazide and a - ethyl - a - (2 - diethylaminoethyl) - phenylacetic acid N-methylanilide. The products are useful as pharmaceutical agents and as wetting agents. |
| priorityDate | 1956-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.