http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-814880-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d1a6faffc381ea8994c77336c1d3c9a0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 |
| filingDate | 1956-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1959-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-814880-A |
| titleOfInvention | Steroid compounds and the preparation thereof |
| abstract | The invention comprises compounds having the formul <FORM:0814880/IV (b)/1> <FORM:0814880/IV (b)/2> <FORM:0814880/IV (b)/3> wherein R represents a carboxylic acid group, preferably having 1-10 carbon atoms or a hydrogen atom and X represents chlorine or fluorine, a process for the preparation of compound VI by treating D 4-9,11b -epoxidopregnene - 14a ,17a , 21 - triol - 3,20 - dione 21-ester with hydrogen fluoride or hydrogen chloride, a process for the preparation of compound VII by treating compound VI with a peracid, and a process for the preparation of compound VIII by reacting compound VII with hydrogen bromide. The 21-esters may be hydrolysed to 21-OH compounds by treatment with a mild alkaline agent, e.g. potassium bicarbonate. Compound VI is produced in the presence of inert solvent, e.g. chloroform, methylene chloride, trichlorethylene, under anhydrous conditions and within the temperature range 0-10 DEG C. Epoxidation is effected within the temperature range 0-10 DEG C., in the presence of an inert solvent, e.g. chloroform, with a peracid, e.g. performic, peracetic, perphthalic or perpropionic acid. The hydrobromination is effected within the temperature range 0-10 DEG C. in an inert solvent, e.g. chloroform, methylene chloride or other halogenated hydrocarbons. Examples describe the preparation of D 4,14-9a -fluoropregnadiene - 11b ,17a ,21 - triol - 3,20-dione 21 acetate, D 4-9a -fluoro-14,15a -epoxidopregnene - 11b ,17a ,21 - triol - 3,20 - dione - 21-acetate and a 4 - 9a - fluoro - 15b - bromopregnene - 11b ,14a ,17a ,21 - tetrol - 3,20 - dione 21-acetate. Specifications 769,998, 770,000, 814,878 and 814,879 are referred to. |
| priorityDate | 1955-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.