| abstract |
A lipid mobilizer may be obtained by dialysing the plasma of stressed mammals and freeze drying the dialysate. Specified nammals are rat, dog, man and preferably horse. Specified stresses are subjection to sub-normal temperature above 0 DEG C., administration of a convulsant drug such as diisopropylfluorophosphate or cholic acid, injection of protamine, anti-kidney serum or preferably cortisone. The lipid mobilizer may be dissolved in pyrogen-free aqueous medium for parenteral administration. The lipid mobilizer has the property when injected into animals of producing hyperlipemia, hyperphagia and depleting fat deposits in the body. It is a non-protein solid, freely soluble in water and physiological salt solution, less soluble in methanol and insoluble in 95 per cent ethanol or acetone, non-extractable by ether from acid or alkaline aqueous solutions, dialysable through semi-permeable membranes against water, comprising a low molecular weight polypeptide as the active ingredient, free of steroids and giving a positive ninhydrin reaction. |