http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-814280-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1e70c0aeade92d7571d955d3b90ea06e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-40 |
| filingDate | 1958-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ff11a25684808c84df96f0f4e63c478 |
| publicationDate | 1959-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-814280-A |
| titleOfInvention | Improvements in or relating to the purification of lysine |
| abstract | Lysine which has been racemized and which contains impurities, such as alpha-amino-epsilon-caprolactam, deleteriously affecting its resolution, is purified by heating it with an aqueous solution of a strong mineral acid, thus producing a lysine capable of more ready resolution. The crude racemized lysine may be obtained by heating optically active lysine with a cation-exchange material, as described in U.S.A. Specification 2,536,360. Specified mineral acids are phosphoric, sulphuric and hydrochloric acids and mixtures of two or more such acids. The concentration of the acid may range from 1 to 50 per cent by weight, that of hydrochloric acid being preferably from 1 to 37 per cent by weight. Preferably from 1.2 to 8 mols. of mineral acid are used per mol. of lysine, the concentration of the lysine in the reaction medium being preferably from 0.5 to 70 per cent by weight, based on the weight of the lysine solution, before addition of the mineral acid. The heat treatment may range from 70 DEG to 220 DEG C. for a duration of 1 to 24 hours. The above purification treatment can be carried out in conjunction with the mineral acid hydrolysis of lysine-yielding intermediates, such as poly-3:5-tetramethylene hydantoin and 5-(delta-aminobutyl) hydantoin, to produce DL-lysine. Thus the crude racemized lysine may be mixed with the lysine-yielding intermediate and the mixture heated with the mineral acid to produce resolvable DL-lysine from the intermediate and resolvable DL-lysine from the crude racemized lysine simultaneously. The examples describe the treatment of lysine which has been racemized by the method of U.S.A. Specification 2,536,360 and its subsequent resolution with L-glutamic acid. |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 20.