http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-809760-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d8c29f83f7f0d659f82a45becb059dbe |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-185 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-03 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-185 |
| filingDate | 1957-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1959-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-809760-A |
| titleOfInvention | Improvements in or relating to pharmacologically active piperazine derivatives and processes for preparing them |
| abstract | The invention comprises piperazine derivatives of the general formula (I): <FORM:0809760/IV (b)/1> (wherein Y is an hydrogen atom or an unsubstituted or halogen, alkyl or alkoxy substituted aralkyl or aralkenyl group, X is -CH2-or -CO-, and R1, R2 and R3 are hydrogen or halogen atoms or alkoxy or alkyl groups containing not more than five carbon atoms) and their preparation by reacting piperazine with halides of the formul : <FORM:0809760/IV (b)/2> and Hal-Y in any desired order, in the presence of an hydrogen halide binding agent which may, if desired, be an excess of the basic component, or, when X is -CH2, by reducing the corresponding compound in which X is -CO- by means of lithium aluminium hydride. In examples: 1 - (4 - tert. - butylcinnamoyl) - 4 - (4-chlorobenzhydryl)-piperazine is prepared by reacting 4 - (tert. - butyl) - cinnamoyl chloride with 1 - (4 - chlorobenzhydryl) - piperazine in benzene; 1 - (4 - methylcinnamyl) - 4 - (4 - chlorobenzhydryl)-piperazine is prepared by reducing 1 - (4 - methylcinnamoyl) - 4 - (4 - chlorobenzhydryl) - piperazin with lithium aluminium hydride in ether, and converted to the hydrochloride; 1-cinnamyl-4-(4-chlorobenzhydryl)-piperazine is obtained by reacting 4-chlorobenzhydryl chloride with 1-cinnamyl-piperazine in toluene, if desired, in the presence of potassium carbonate, and converted to the hydrochloride. The physical and pharmacological data relating to other compounds of the general formula (I) in which Y is an hydrogen atom or a benzyl, cinnamoyl, benzhydryl or p-methyl-, p-isopropyl-, p-methoxy-, p-methoxy-p1-chloro-, p-methyl-p1-chloro- or p-isopropyl-p1-chlorobenzhydryl radical and one or more of R1, R2 and R3 are methoxy or isopropyl radicals are also given. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102942538-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102942538-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3422195-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0209843-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0244319-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2497512-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101235020-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3625965-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0551617-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2474031-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4859673-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0551617-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0399569-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0157420-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0244319-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0187639-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0209843-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0000333-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0000333-A2 |
| priorityDate | 1956-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 68.