http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-806772-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_571b8abacacea64d3f7089d0983b8b3b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-94 |
| filingDate | 1957-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1958-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-806772-A |
| titleOfInvention | Diaminoquinazolines and method of preparing |
| abstract | The invention comprises 2,4-diaminoquinazolines of the formula <FORM:0806772/IV (b)/1> (wherein R1, R2, R3 and R4 are hydrogen atoms or lower alkyl groups, at least one being a lower alkyl group and the total number of carbon atoms in all the alkyl groups present being one to five), and the preparation thereof by (a) reacting the corresponding 2 : 4-dihalogenoquinazolines with ammonia or (b) treating the corresponding 2 : 4-dihydroxyquinazoline with a halide or oxyhalide of phosphorus or a mixture of two such compounds to produce a 2,4-dihalogenoquinazoline and reacting the latter with ammonia. In examples, 6-methyl-2,4-dihydroxyquinazoline is reacted with a mixture of phosphorus pentachloride and phosphoryl chloride to form the corresponding 2,4-dichloro compound which in turn is treated with alcoholic ammonia to form 6-methyl-2,4-diaminoquinazoline; similarly is prepared 2,4-diamino-6,7-dimethylquinazoline. In further examples, 2,4-diamino-8-methyl-, and 2,4-diamino-6,8-dimethylquinazolines are prepared in like manner, phosphoryl chloride in dimethyl aniline being used in the chlorination step, and 2,4-diamino-6-ethyl-and 2,4-diamino-5-isopropyl-8-methyl quinazolines are similarly prepared using phosphoryl chloride alone. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0322133-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102918051-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5064833-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9003695-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-8905297-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102918051-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9003695-A3 |
| priorityDate | 1956-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.