http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-804480-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2dbb2d7ecbd600cf89fbdd230f4a466c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 |
| filingDate | 1956-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1958-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-804480-A |
| titleOfInvention | Improvements in or relating to steroids |
| abstract | The invention comprises 22a(25D)-spirost-1,4-diene-3-one of the formula <FORM:0804480/IV (b)/1> and the preparation thereof by reacting a solution of ruscogenin in an inert solvent at an elevated temperature with a hydrogen accepter of high oxidation potential selected from ketones and quinones in the presence of a catalyst consisting of a metallic alcoholate or phenate. The above process may be modified in that the hydroxyl group in the 1-position of ruscogenin is blocked with an ester group, e.g. by reaction with an acid anhydride or chloride such as acetic anhydride, the ester is reacted with the hydrogen accepter to form the ester of 1-hydroxy - 22a(25D) - spirost - 4 - en - 3 - one and this compound is reacted with an alcoholic solution of an alkali metal hydroxide at an elevated temperature. The reaction in the inert solvent may be effected at or in the neighbourhood of the boiling temperature of the reaction mixture. Suitable inert solvents are aromatic hydrocarbons such as benzene, toluene and xylene. Suitable hydrogen accepters are acetone, cyclohexanone and p-benzoquinone. Suitable catalysts are aluminium t-butylate, isopropylate and phenate. Detailed examples are given in which also the 2,4-dinitrophenylhydrazone of 22a(25D)-spirost - 1,4 - diene - 3 - one and the diacetyl and 3-acetyl derivatives of ruscogenin are prepared. |
| priorityDate | 1955-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.