http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-800797-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d1a6faffc381ea8994c77336c1d3c9a0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 |
| filingDate | 1956-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1958-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-800797-A |
| titleOfInvention | Steroid compounds and the preparation thereof |
| abstract | The invention comprises compounds having the formula: <FORM:0800797/IV (b)/1> wherein R represents hydrogen or acyl, and a process for preparing hydrocortisone or an ester thereof which comprises hydrogenating in the presence of zinc-acetic acid D 4,6-pregnadiene-11b ,17a ,21 - triol - 3,20 - dione or the corresponding ester thereof. D 4,6-pregnadiene-11b , 17a ,21 - triol - 3,20 - dione is obtained by subjecting D 4,6 - 17a ,21 - diol - 3,20 - dione to the oxidizing activity of an organism of the genus Curvularia. Examples (1)-(4) describe the preparation of D 4,6-pregnadiene-11b ,17a ,21-triol - 3,20 - dione utilizing c. lunata, C. pal-lescens and C. brachyspora; Example (5) describes the esterification in 21-position of D 4,6-pregnadiene - 11b ,17a ,21 - triol - 3,20 - dione by means of acetic acid, propionic acid, butyric acid, trimethylacetic acid, cyclopentylpropionic acid, undecenoic acid, benzoic acid, cyclohexane carboxylic acid, oxalic acid, malonic acid, succinic acid, phthalic acid and stearic acid; Example VI describes the preparation of hydrocortisone-21-acetate. Specifications 769,998 and 770,000 are referred to.ALSO:A therapeutic composition comprises D 4,6-pregnadien p - 11b ,17a ,21 - triol - 3,20 - dione or a 21-ester thereof and a pharmaceutical carrier. A solution for injection comprises the sodium salt of the hemisuccinate of D 4,6-pregnadien-11b ,17a ,21 - triol - 3,20 - dione, chlorobutanol, saline or glucose in aqueous solution. For oral administration D 4,6 - pregnadien - 11b ,17a ,21-triol-3,20-dione may be combined with starch and milk sugar to form tablets. Elixirs containing sweetening and flavouring agents may be used. Specifications 769,998 and 770,000, [both in Group IV (b)], are referred to. |
| priorityDate | 1955-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 61.