http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-798666-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6382e2e3b089a524e41b2041d0c58caa |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D251-26 |
| filingDate | 1956-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1958-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-798666-A |
| titleOfInvention | A process for the production of hydrohalides of barbituric acid derivatives |
| abstract | The invention comprises a process for the production of barbituric acid derivatives of the general formula: <FORM:0798666/IV (b)/1> wherein R1 is an alkyl radical, R2 an alkyl or aryl radical, R3 alkyl radicals which can if desired form a heterocyclic ring in conjunction with the adjacent nitrogen atom, X is an oxygen or sulphur atom and Hal is a halogen atom, by (1) reacting a barbituric acid of the general formula: <FORM:0798666/IV (b)/2> with an aminoethyl halide of the general formula: <FORM:0798666/IV (b)/3> in the presence of an organic solvent comprising a ketone, an ester, or an alcohol; or (2) reacting a metal salt of a barbituric acid of the general formula (II), in an organic solvent, as above, with a hydrohalide of an aminoethyl halide of the general formula (III). In examples, 5 : 5-diethyl - or 5 : 5 - phenyl - ethyl - barbituric acids are dissolved in hot acetone and mixed with piperidino ethyl chloride when the 5 : 5-disubstituted - 3 - piperidinoethyl - barbituric acid derivative is formed and crystallizes from the solution; the sodium salt of 5 : 5-phenyl-ethyl-barbituric acid is suspended in acetone and diethylaminoethyl chloride hydrochloride added; the solution is filtered from the sodium chloride formed and the filtrate heated, when 5 : 5 - phenyl - ethyl - 3 - diethylaminoethyl-barbituric acid hydrochloride is formed and crystallizes from solution. |
| priorityDate | 1956-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.