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http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-43
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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-46
filingDate 1956-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1958-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber GB-794798-A
titleOfInvention Pharmaceutical compositions
abstract A non-toxic effervescent pharmaceutical composition comprises a solid organic acid material such as tartaric, citric or succinic acid or their potassium or sodium acid salts and a material such as sodium bicarbonate or carbonate which reacts with the organic acid material on contact with moisture to form a gas and a surface-active agent. The surface-active agent may be cationic, anionic, or nonionic. In the first case it should preferably amount by weight to not more than 0.2 per cent of the composition; in the second, not more than 2 per cent; in the third, not more than 25 per cent. A mixture of cationic and nonionic or anionic and nonionic surface-active agents may be used. The pH of the dissolved composition in water should be from 2 to 10 and preferably 3 to 7. Specified surface-active agents are (a) cationic: coconut alkyl dimethylbenzyl ammonium chloride, cetyl trimethyl ammonium chloride, dodecyl dimethylallyl ammonium chloride, cetyl dimethylbenzyl ammonium chloride; (b) anionic: sodium lauryl sulphate, sodium hepta-decyl sulphate; (c) nonionic: the polyethylene glycol mono ester of ricinoleic acid or lauric acid, lauryl ether of polyalkoxyethanol, p-diisobutyl or p-triisopropyl phenoxypolyethoxyethanol having approximately 9 to 11 ethoxy groups. Therapeutic agents may be added for their specific effect: specified are propylparahydroxybenzoate, oxyquinoline sulphate, procaine hydrochloride, butethamine formate and hydrochloride, sulphacetamide, p-nitrosulphathiazole, bacitracin, aureomycin hydrochloride, potassium penicillin. Diluents such as starch and sucrose may be added and the composition may be tabletted. Many examples are given.
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