http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-794436-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5528d8d64c9da539b3fa8028a22bede6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J47-014 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J47-00 |
| filingDate | 1955-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1958-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-794436-A |
| titleOfInvention | Process of recovering basic antibiotics by adsorption on cation exchangers |
| abstract | 794,436. Recovery of basic antibiotics from broths. OLIN MATHIESON CHEMICAL CORPORATION. April 18, 1955 [June 1, 1954], No. 11142/55. Class 2 (3). A basic antibiotic other than polymycin is recovered from a fermentation broth by contacting the whole broth with a particulate cation exchanger deriving its exchange capacity essentially from carboxylic acid groups and particularly a cation exchange resin, separating the antibiotic-stripped whole broth from the particles of exchanger and eluting the antibiotic from the exchanger. Specified basic antibiotics are streptomycin, streptothricin and neomycin. Preferred cation exchangers are resins deriving their exchange properties from carboxylic groups, e.g. "Amberlite" (Registered Trade Mark) IRC-50 and used in its salt form, e.g. sodium cycle. Other resins are Alkalex, Duolite CS100, "Permutit" (Registered Trade Mark) 216 and H-70 and Wofatit C. The whole broth is used as obtained from the fermenter with or without acidification and neutralization. It may be diluted with water to produce a suitable viscosity and may be passed through a screen to remove large particles of solids. The adsorption is batchwise or continuous, in columns or tanks, and may be arranged on the counter-current principle. Particles of cationexchange carried forward by the stripped broth are held back by a screen conveniently of 50 to 80 mesh, in which case, prior to the adsorption step, the whole broth would be prescreened at 80 mesh or below, preferably 100-200 mesh, and the cation-exchanger would be prescreened at 40 mesh. The screen is either inside or outside the column and clogging of the screen is prevented by (a) an agitator placed in the stripped broth near to the screen ; (b) a vibrator actuating the screen; or (c) playing a jet of water on the screen. The process may be operated downflow or upflow, which latter is preferred as there is then less tendency for the screen to clog. The antibiotic is eluted from the saturated cation-exchanger by means of an acid, e.g. nitric, sulphuric or hydrochloric, and the exhausted exchanger is then regenerated by a base such as sodium hydroxide, potassium hydroxide or ammonia, or a salt. Specification 758,041 is referred to. |
| priorityDate | 1954-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.