http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-777685-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-26 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C59-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C59-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-72 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-90 |
| filingDate | 1953-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1957-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-777685-A |
| titleOfInvention | Polyhydrophenanthrene compounds and their preparation |
| abstract | The invention comprises compounds having the skeleton formul : <FORM:0777685/IV(b)/1> <FORM:0777685/IV(b)/2> <FORM:0777685/IV(b)/3> wherein X represents a keto group (with a double bond in the 8(8a)-position), a ketal or cyclic ketal grouping (with a double bond in the 8a(9)-position) or an enol ether group (with double bonds in the 7(8)- and 8a(9)-positions), and R0 represents an alkyl radical and their preparation. Compounds having the formula 5 are obtained by reducing a compound having the formula: <FORM:0777685/IV(b)/4> with the borohydride of an alkali metal or alkaline earth metal, e.g. with sodium borohydride. Compound 5 is in turn reduced with alkali metal, e.g. lithium, in liquid ammonia to produce compound 4. Alternatively compound 3 may be reduced directly to compound 4 with alkali metal, e.g. sodium or potassium in ethanol or butanol. Compound 4 may be esterified to form compound 6, e.g. with diazomethane or with methyl iodide and potassium carbonate. The compounds are blocked in 7-position in all these reactions, and the resulting products may be subsequently converted to 7-keto compounds by hydrolysis with acid, or by treatment with p-toluene-sulphonic acid in acetone. Examples describe the production of 1-carboxymethylene - 2 - methallyl - 2,4b - dimethyl - 4 - hydroxy - 7 - ethylenedioxy - 1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydrophenanthrene and the corresponding 7-keto compound, 1 - carboxymethyl - 2 - methallyl - 2,4b - dimethyl - 4 - hydroxy - 7 - ethylenedioxy - 1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydrophenanthrene and the corresponding 7-keto compound and 2-carbomethoxymethyl - 2 - methallyl - 2,4b - dimethyl - 4 - hydroxy - 7 - ethylenedioxy - dodecahydrophenanthrene and the corresponding 7-keto compound. Various stereoisomers of the products in the examples are specified. Specifications 763,208 also is referred to. |
| priorityDate | 1952-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.