http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-774989-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D457-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-48 |
| filingDate | 1954-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1957-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-774989-A |
| titleOfInvention | Improvements in or relating to novel chemical compounds useful in the synthesis of lysergic acid and its homologues and process for preparing such compounds |
| abstract | The invention comprises halogenated octahydro-indolo-quinolines (ergolenes) of the formula <FORM:0774989/IV(b)/1> where X is chlorine or bromine, R is C1-C8 alkyl, monocyclic aryl or monocyclic aralkyl having 1-8 carbon atoms in the side chain, and R1 is C1-C8 alkyl, and acid addition salts thereof. These are made by halogenating the compounds (X=OH)-see Specification 774,988 -to replace the hydroxy group by halogen. If desired, the starting materials (which are used in the form of their salts) may be treated with a strong acid to invert the stereo-configuration of the hydroxyl group. Examples are given of the preparation of 4-acetyl-9-chloro-7-methyl-10-ergolene from the hydroxy compound and thionyl chloride, isolated as hydrochloride; the 9-bromo compound is made similarly. R may also be phenyl and R1 may be ethyl or propyl. The products are intermediates in the synthesis of lysergic acid and its homologues. |
| priorityDate | 1954-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.