http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-769226-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c902faf6ae746c51fc8010672fc22894 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P33-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P33-00 |
| filingDate | 1954-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1957-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-769226-A |
| titleOfInvention | Process for the production of 17-ketosteroids |
| abstract | 17-Ketosteroids, especially of the androstane and etiocholane series, are produced by contacting a fungus of the genus Penicillium, or oxygenating substances produced thereby, with a 20-oxygenated steroid under aerobic conditions, and isolating the resulting 17-ketosteroid. The process may be carried out by growing the fungus (preferably under submerged aerobic conditions with agitation) in the presence of a nutrient medium (e.g. one containing assimilable non-steroidal carbon, such as a carbohydrate, and preferably also nitrogen and phosphorus) and of a 20-keto-pregnane or -allopregnane. Examples describe the preparation of: (1) 4-androstene-3:17-dione (and some 20b -hydroxy-4-pregnen-3-one, the two products being separated by chromatography) from progesterone by means of P. lilacinum Thom; (2),(4),(5) and (7) 4 - androstene - 3:17 - dione (and 20a :21 - dihydroxy - 4 - pregnen - 3 - one) from 11 - desoxycorticosterone acetate by means of P. canescens, P. nigricans, P. charlesii and P. lividum; (3) 14a - hydroxy - 4 - androstene - 3:17 - dione from 14a -hydroxyprogesterone by means of P. lilacinum; (6) and (9) 4-androstene - 3:17 - dione (and, in the former case, 20a :21 - dihydroxy - 4 - pregnen - 3 - one) from progesterone by means of P. brevi-compactum and P. frequentans; (8) adrenosterone from 11-ketoprogesterone by means of P. expansum; (10) 4-androstene-3:17-dione from 17a -hydroxyprogesterone by means of P. lilacinum; (11) 11a -hydroxy - 4 - androstene - 3:17 - dione from 11a :17a - dihydroxyprogesterone by means of P.thomii; (12) etiocholane-3:6:17-trione from pregnane - 3:6:20 - trione by means of P. novae-zeelandiae; (13) 6b -hydroxy-4-androstene-3:17-dione from 6b -hydroxyprogesterone by means of P. citrinum; (14) etiocholane-3:17-dione from pregnane-3:20-dione by means of P. canescens; (15)-(21) androstane-3:11:17-trione from allopregnane-3:11:20-trione, 4-androstene - 3:17 - dione (and 17a :20a :21-trihydroxy - 4 - pregnen - 3 - one) from 17a :21-dihydroxy - 4 - pregnene - 3:20 - dione, adrenosterone from cortisone and from cortisone acetate, 11a - hydroxy - 4 - androstene - 3:17 - dione from 11a :17a :21-trihydroxy-4-pregnene-3:20 - dione, 3a :11a - dihydroxyetiocholan - 17 - one from 3a :11a :17a - trihydroxypregnan-20-one, and etiocholane-3:12:17-trione from pregnane-3:12:20-trione, all by means of P. lilacinum. Lists are given of additional starting materials and products, fungi and nutrient medium ingredients. Specifications 723,749, 734,798 and U.S.A. Specifications 2,288,854 and 2,602,769 are referred to. |
| priorityDate | 1953-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 70.