http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-767180-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d1a6faffc381ea8994c77336c1d3c9a0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 |
| filingDate | 1953-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1957-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-767180-A |
| titleOfInvention | Improvements in or relating to steroid compounds and preparation thereof |
| abstract | The invention comprises an 8-unsaturated-11-keto-14-hydroxy derivative of ergosterol, and the preparation thereof by contacting an 11,14-peroxide 8,9-unsaturated derivative of ergosterol with an inorganic alkaline material, e.g. alumina, potassium-t.-butoxide, potassium bicarbonate, sodium hydroxide, potassium hydroxide and sodium bicarbonate. The reaction may be effected in a solvent such as benzene, diethyl ether, toluene, pentane, dioxane, ethyl acetate, ethylene glycol, acetone or a lower alkanol. The starting peroxides may bear double bonds at nuclear or side chain positions as well as at 8, 9, and also keto, hydroxyl and groups hydrolysable thereto in 3-position, short side chains at C10 and C13, and groups such as alkyl or alkenyl in 17-position. The 11-keto-14-hydroxy derivative so produced may be dehydrated, e.g. with an acidic dehydrating agent, to produce an 8,14-unsaturated 11-keto derivative of ergosterol and subsequently reduced, e.g. with hydrogen in the presence of a hydrogenation catalyst, to produce an 8,9-unsaturated 11-keto derivative of ergosterol. Examples disclose the production of ergosta-6,8,22 - trien - 11 - one - 3b ,14 - diol 3 - acetate, ergosta - 8,14,22 - trien - 11 - one - 3b - ol acetate, ergosta - 8 - en - 11 - one - 3b ,14 - diol 3 - acetate, ergosta - 6,8,14,22 - tetraen - 11 - one-3b -ol and the acetate thereof, ergost-8-en-11 - one - 3b - ol acetate, and 8,9 - isoergostan - 11 one - 3b - one - 3b - ol acetate. Specifications 726,920 and 767,181 are referred to. |
| priorityDate | 1953-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.