http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-765086-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07f01faf8e427e05e524ad64206bc73c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-585 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5084 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5078 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate | 1954-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1957-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-765086-A |
| titleOfInvention | Anticholinergic preparation |
| abstract | 765,086. Antispasmodic preparations. SMITH KLINE & FRENCH INTERNATIONAL CO. Nov. 19. 1954, No. 33629/54. Class 81(1) An antispasmodic preparation comprises an anticholinergic which, after an initial dose, is gradually released to maintain a substantially constant therapeutic level e.g. over 10 to 12 hours. The preparation takes the form of a gelatin capsule 2, containing uncoated pellets 3 to provide the initial dose equivalent to 0.05 to 1.0 mg of atropine sulphate, and more than fifty pellets 4, 6 and 8, coated with various thicknesses of an ingestible material resistant to disintegration in the gastrointestinal tract and containing from 100 to 1,000 per cent by weight of the initial dose. The preparation may also contain from-10 to 200 mg. of a sedative in the initial dose and from 100 to 1,000 per cent by weight of the initial sedative dose in the coated pellets. The anticholinergic may be a belladonna type alkaloid such as hyoscyamine, scopolamine, atropine and their inorganic or organic salts, e.g. hydrochloride, sulphate, phosphate, maleate, tartrate, and succinate, or quarternary compounds such as methantheline bromide, diophenylmethanil methyl sulphate, propantheline bromide, methyl atropine nitrate, homatropine methyl bromide, amprotropine phosphate, and 6, 7-epoxy-tropanyl-3-tropate-N-methyl bromide or the sulphate, nitrate, halide or phosphate of the quarternary compounds, which may be present as pellets of a mixture, or as a mixture of pellets each containing different substances. Sedatives which may be present are barbital, phenobarbital, amobarbital, vinbarbital, probarbital calcium, pentabarbital sodium, butethal, hexethal, cyclobarbital, aprobarbital, diallylbarbituric acid, allylbarituric acid, butallylonal, hexobarbital, secobarbital, thiopental, and mephobarbital. The pelletes may be prepared using nitrocellulose spheres, starch, rape seeds, sugar or farina, or sulphonic or carboxylic ion exchange resins e.g. copolymus of methacrylic acid and dibenzene. Coating materials are beeswax, Japan wax, paraffin, carnauba, bayberry or spermaceti wax, alcohols or acids having from 12 to 22 carbon atoms or esters of said alcohols and acids e.g. glyceryl mono, di or tristearate, cetyl palmitate, diglycol stearate glyseryl myristate, triethylene glycol monostearate, cetyl alcohol, cholesterol, stearyl alcohol, or mixtures thereof, which may be used in the form of a solution in ethyl alcohol or carbon tetrachloride. The anticholinergic may be extended with, for example, calcium sulphate dihydrate, powdered starch or acacia, prior to use. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4717569-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2159714-A |
| priorityDate | 1954-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 110.