http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-750918-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a0b4dd29891f892c9208aac43470acd3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 |
| filingDate | 1953-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1a761f82f9547578f8b7639a442e102 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78b94f8554af17597db90aabcb69332a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_414af2bd70a599f0cade6d782b585334 |
| publicationDate | 1956-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-750918-A |
| titleOfInvention | Improvements in or relating to the preparation of steroid substances |
| abstract | D 4-3-Keto-steroids are prepared by reduction of D 4-2-iodo-3-keto-steroids with hydrogen iodide, preferably formed from excess alkali metal iodide and a non-oxidizing acid, particularly oxalic, tartaric or hydrochloric acid. The intermediate 2-iodosteroids are prepared from 3-keto-2 : 4-dibromoallosteroids by treatment with excess alkali metal iodide in an inert polar solvent, e.g. acetone, methyl ethyl ketone, tert.-butanol, tetrahydrofuran and methyl cyanide. In examples (1) 21-acetoxy- 2 : 4-dibromo - 17a - hydroxy - 3 : 11 : 20 - triketoallopregnane is refluxed with sodium iodide in acetone containing bromo acetone, oxalic acid is then added and mixture again refluxed, the solution is then concentrated, the iodine removed with thiosulphate, and cortisone 21-acetate extracted with ethyl acetate; (2) 17 : 21-diacetoxy - 2 : 4 - dibromo - 3 : 11 : 20 - triketo allopregnane is treated as in (1), effecting the removal of iodine from the ethyl acetate extract by treatment with zinc dust and acetic acid, after which cortisone diacetate is isolated on evaporation of the solvent; (3) as in (2) using 2 : 4-dibromo dihydro allocortisone acetate and acidifying with tartaric or hydrochloric acid to give cortisone acetate after purification. Specification 750,330 is referred to. Reference has been directed by the Comptroller to Specification 693,991. |
| priorityDate | 1953-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.