http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-744961-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d037bc74e34c7d73dd883f208aef0518 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-44 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-44 |
| filingDate | 1953-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd0e604b97c1a44d48ae369401bcd8e9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_171909c329868abf9bf556d507811efd |
| publicationDate | 1956-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-744961-A |
| titleOfInvention | Unsaturated nitro thiophene derivatives |
| abstract | The invention comprises compounds of the formula <FORM:0744961/IV(a)/1> wherein R is hydrogen or halogen, Z is a hydroxy group or a lower aliphatic alkoxy group of 1 to 8 carbon atoms or an amino group, or R and Z are both hydrogen, also a compound of the formula <FORM:0744961/IV(a)/2> The above acids in which Z is a hydroxy group may be made by oxidizing the corresponding aldehydes and may in turn be converted into the esters or amides. In examples (1) acetaldehyde is added to 5-nitro-2-thiophenealdehyde alcoholic potassium hydroxide is added followed by an excess of acetic anhydride and the mixture is heated to give 5-nitro-2-thienyl acrolein, reaction of this with acetic anhydride in the presence of sulphuric acid gives 5-nitro-2-thienyl acrolein diacetate of the formula given above; (2) 5-nitro-2-thiophenealdehyde is reacted with sodium acetate and acetic anhydride to give 5-nitro-2-thiopheneacrylic acid which is esterified to give the ethyl ester or treated with phosphorus pentachloride followed by ammonia to give the amide, and (3) a -bromo - b - (5 - nitro - 2 - thenyl) - acrolein is oxidized with chromium trioxide to a -bromo-b -(5-nitro-2-thienyl) acrylic acid which is converted into the corresponding ethyl ester and amide. |
| priorityDate | 1953-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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