http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-739597-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c902faf6ae746c51fc8010672fc22894 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J21-00 |
| filingDate | 1953-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1955-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-739597-A |
| titleOfInvention | Steroid ketals |
| abstract | The invention comprises 11b -hydroxypro-gesterone - 3 : 20 - diketals of the formula <FORM:0739597/IV (b)/1> wherein R is hydrogen or an alkyl radical containing from one to six carbon atoms, inclusive, and n is one or two, provided that the total number of carbon atoms in the polymethylenedioxy residue does not exceed 8, and also a process for their preparation which comprises treating the corresponding 11-keto-3 : 20-diketal with a reducing agent, classified as a mixed metal hydride, or hydrogen in the presence of a hydrogenation catalyst. The reaction is conducted in an inert solvent, e.g. ether, benzene, tetrahydrofuran and petroleum ether, and when using a mixed hydride, e.g. lithium aluminium hydride, lithium borohydride or sodium borohydride, the reaction product is hydrolysed with water. In examples (1) 11b -hydroxyprogesterone 3 : 20 - ethylene glycol diketal is prepared from the corresponding 11-keto compound by reduction with lithium aluminium hydride in ether or benzene. Other examples describe the formation of the corresponding 11b - hydroxy - 3 : 20 - diketals in which the polymethylenedioxy residue is derived from propane - 1 : 2 or 1 : 3 - diol; butane - 1 : 3-diol and octane-1 : 2-diol. (2) 11b -hydroxyprogesterone-3 : 20-ethylene glycol diketal is also prepared using sodium borohydride in aqueous isopropanol, and lithium borohydride in aqueous ethanol as the reducing agents. A further list of other 11b -hydroxyprogesterone-3 : 20-diketals is provided. Specification 734,805 is referred to. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3166550-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3143559-A |
| priorityDate | 1952-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.