http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-735321-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c902faf6ae746c51fc8010672fc22894 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 |
| filingDate | 1952-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1955-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-735321-A |
| titleOfInvention | Process for the preparation of 3-keto-bis-nor-4-cholen-22-al |
| abstract | 3 - Keto - bisnor - 4 - cholen - 22 - al is prepared by selectively ozonizing the 22-double bond of 4 : 22 - ergostadien - 3 - one, without concurrently ozonizing the 4-double bond thereof, to produce 4 : 22 - ergostadien - 3-one - 22(23) - mono - ozonide, and reductively decomposing said ozonide. The required 4 : 22-ergostadien - 3 - one is obtained by selective hydrogenation of 4 : 6 : 22-ergostatrien-3-one in the presence of a palladium catalyst. Specified solvents for the ozonization are chloroform, carbon tetrachloride, ether, methanol, ethyl acetate, acetic acid and methylene chloride, and the reaction is preferably effected in the presence of an acid-binding agent, e.g. pyridine picoline, triethylamine or N-methyl piperidine. In an example 4 : 6 : 22-ergostatrien-3-one is hydrogenated in methanol containing potassium hydroxide, using a palladium-charcoal catalyst, and the resultant 4 : 6-ergostadiene-3-one ozonized in methylene chloride containing pyridine to yield the mono-ozonide, which is decomposed with zinc dust and acetic acid to yield 3-keto-bisnor-4-cholen-22-al. Specification 679,775 is referred to. |
| priorityDate | 1952-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.