http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-709376-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d1a6faffc381ea8994c77336c1d3c9a0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H23-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H23-00 |
| filingDate | 1951-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1954-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-709376-A |
| titleOfInvention | Improvements in or relating to antibiotic pharmaceutical compositions |
| abstract | A mixture of the antibiotic oxytetracycline (also known as terramycin) and Vitamin B12 suitable for use in pharmaceutical compositions (see Group VI), is obtained by purifying a fermentation broth of Streptomyces rimosus by (a) solvent extraction or (b) adsorption. A water-immiscible alcohol, e.g. butanol, pentanol, benzyl alcohol, cresols, or mixtures thereof, is used in (a) at a pH of 2 or less. The active substances are recovered by removing the solvent, or by re-extracting with water and an organic solvent, e.g. pentane, which is a nonsolvent for the active substances. For (b) the active substances are absorbed on carbon at a slightly acid pH, and eluted therefrom by dilute acid, or a mixture of dilute acid and a water-immiscible organic solvent. Specification 709,347, [Group I], is referred to.ALSO:A pharmaceutical composition for use in vitamin therapy and as dietary supplements comprises a member of the vitamin B12 complex e.g. vitamin B12, vitamin B12a and vitamin B12b, and the antibiotic oxytetracycline, also known as terramycin, as such or in the form of a metal or acid salt, especially terramycin p hydrochloride. The compositions are administered orally as elizirs, aqueous solutions of a suitable pH, tablets, capsules and powders. 0.2 mg to 20 mg of terramycin hydrochloride for each microgram of vitamin B12 is suitable for administration in anemia. Fermentation broths containing both terramycin and vitamin B12, e.g. by culturing S rimosus, may be purified by absorption or extraction (see Group IV(b)), to produce a product which is used in the above pharmaceutical compositions as such, or with the further addition of one or other of the active components to produce a composition of the desired content. Specification 709,347, [Group I], is referred to. |
| priorityDate | 1951-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.