http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-704053-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dc2f7134efa50484bb359fda73782848 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C335-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C335-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C335-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C335-16 |
| filingDate | 1952-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1954-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-704053-A |
| titleOfInvention | Manufacture of para-substituted phenyl-thioureas |
| abstract | The invention comprises para-substituted phenylthioureas of the formula <FORM:0704053/IV(b)/1> in which R1 is an alkoxy, alkylmercapto, hydroxyalkoxy, alkoxyalkoxy or alkylmercapto-alkoxy group, and R2 is an alkylmercapto, hydroxyalkoxy, alkoxyalkoxy or alkylmercapto-alkoxy group, and in which the sum of the carbon atoms and oxygen and/or sulphur atoms in each of the groups R1 and R2 is greater than 2 and less than 7. They may be prepared, for example, by reacting a suitably substituted aniline with carbon disulphide or thiophosgene to give compounds in which R1 and R2 are alike, or with a substituted phenyl isothiocyanate to give compounds in which R1 and R2 differ. The reactions may be carried out in a solvent such as alcohol or dioxan. A catalyst such as hydrogen peroxide, sulphur, potassium ethyl xanthate or potassium hydroxide may be present in the reaction with carbon disulphide, and alkali metal hydroxide or carbonate may be present to bind hydrochloric acid in the reaction with thiophosgene. Examples are given of the reaction of (1) p-(2 - ethoxyethoxy) - aniline or p - (2 - hydroxyethoxy)-aniline with carbon disulphide, (2) p-(b - ethylmercaptoethoxy) - aniline with carbon disulphide, (3) p-(b -ethoxyethoxy)-aniline or p-(b -hydroxyethoxy)aniline with p-phenetyl isothiocyanate, (4) b - ethylmercapto - p - phenetidine (obtained by reacting acetyl-b -bromophenetidide with ethyl mercaptan and hydrolyzing) with p-phenetyl isothiocyanate, (5) p-amino-thiophenol propyl ether (obtained from p-acetylamino-thiophenol and n-propyl bromide followed by hydrolysis) and carbon disulphide, (6) p-aminothiophenol propyl ether with p-phenetyl isothiocyanate, (7) p-aminothiophenol isopropyl ether with p-phenetyl isothiocyanate, (8) p-aminothiophenol isoamyl ether with carbon disulphide, (9) p-aminothiophenol isoamyl ether with p-phenetyl isothiocyanate, (10) p-aminothiophenol isoamyl ether with p-butoxyphenyl isothiocyanate, (11) p-aminothiophenol ethyl ether with p-phenetyl isocyanate, (12) p-aminothiophenol ethyl ether with carbon disulphide, (13) p-aminothiophenol butyl ether with p-phenetyl isothiocyanate, (14) p-aminothiophenol butyl ether with carbon disulphide, (15) p-aminothiophenol n-amyl ether with phenetyl isothiocyanate, and (16) p-aminothiophenol n-amyl ether with carbon disulphide. |
| priorityDate | 1951-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.