http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-701803-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_571b8abacacea64d3f7089d0983b8b3b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C225-16 |
| filingDate | 1951-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d59e6f6dbf13f100dee8fc147b6407d5 |
| publicationDate | 1954-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-701803-A |
| titleOfInvention | Diphenyl ketones of pharmaceutical value and the preparation thereof |
| abstract | The invention comprises the compounds 6-ethylmethylamino-5-methyl-4, 4-diphenylhexan-3-one and 6-ethylmethylamino-4, 4-diphenylheptan-3-one, and their salts. The compounds are analgesics and may be prepared by treating 3-ethylmethylamino-2-methyl-1, 1-diphenyl-propyl cyanide or 3-ethylmethylamino-1, 1-diphenylbutyl cyanide, respectively, with ethyl magnesium bromide. In examples, ethylmethylamine is heated with propylene oxide to give 1-ethylmethylamino-2-propanol which is reacted with thionyl chloride in chloroform to yield 1-ethylmethylamino-2-chloropropane; this is then refluxed with diphenylmethyl cyanide and sodamide in benzene to produce a mixture of the isomers 3-ethylmethylamino-1, 1-diphenylbutyl cyanide and 3-ethylmethylamino-2-methyl-1, 1-diphenylpropyl cyanide. After separation, these compounds are reacted with ethyl magnesium bromide according to the Grignard process. The oxalate and the hydroiodide of 6-ethylmethylamino-5-methyl-4, 4-diphenylhexan-3-one, and the hydrobromide of 6-ethylmethylamino-4, 4-diphenylheptan-3-one are described. The Provisional Specification refers to Specifications 654,975, 677,522 and 688,481. |
| priorityDate | 1951-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.