http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-695391-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76195fd1cd08192222699d8e7a88c231 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-238 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-238 |
| filingDate | 1950-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1953-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-695391-A |
| titleOfInvention | Process for producing a dihydrostreptomycin |
| abstract | A streptomycin-containing liquid obtained from Streptomyces griseus as described in Specification 610,570 is treated with activated charcoal and the streptomycin is eluted from the charcoal with dilute hydrochloric acid at 70 DEG C. The eluate is adjusted to a pH value of 6.5 with sodium hydroxide and then electrolytically reduced, adding hydrochloric acid until reduction is complete. The catholyte is then mixed with an aqueous solution of the sodium salt of sulphated 3,9-diethyl tridecanol-6, and the precipitate is filtered off and dried. It is then dissolved in methanol and impurities filtered off. The filtrate is diluted with water and heated together with a neutral anion-exchange resin, and concentrated hydrochloric acid is added to maintain the pH value between 3 and 3.5 for half-an-hour. The pH value is then allowed to rise between 5 and 5.5 and the resin filtered off. The filtrate is then vacuum-distilled to remove the methanol and the residual solution is freeze-dried, yielding the hydrochloride of the dihydrostreptomycin. |
| priorityDate | 1949-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.