http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-680155-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_14effe3850d2129f863b969dac4f1db8 |
| filingDate | 1950-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1952-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-680155-A |
| titleOfInvention | Improvements relating to sulphonamide compounds |
| abstract | The invention comprises N-acyl-4-hydroxy-benzenesulphonamides of the general formula <FORM:0680155/IV (b)/1> in which R is an aliphatic, heterocyclic or substituted phenyl radical. It also comprises a process for preparing N-acyl-4-hydroxybenzene sulphonamides by acylating the amide nitrogen of a 4-acyloxybenzenesulphonamide and hydrolysing the acyloxy group, or by acylating both the amide and the hydroxyl groups and selectively hydrolysing the acyloxy group. In examples: (1) 1 - phenol - 4 - sulphonamide is heated with acetic anhydride and hydrolysed with caustic soda to give N-(4-hydroxyphenyl-sulphonyl) acetamide; (2) benzoyl chloride is added to 1-phenol-4-sulphonamide in pyridine and the product hydrolysed to yield N-(4-hydroxybenzene-sulphonyl) benzamide; (3) N-(4-hydroxybenzenesulphonyl) furamide is prepared as in (2) but using furoyl chloride; (4) 4-benzoxybenzenesulphonamide (prepared from 4 - benzoxybenzenesulphonyl chloride and aqueous ammonia) is heated with benzoyl chloride in pyridine and then hydrolysed to yield N - (4 - hydroxybenzenesulphonyl) benzamide; (5) 4-benzoxybenzenesulphonamide is heated with phenylacetyl chloride in pyridine and hydrolysed to give N-(4-hydroxybenzenesulphonyl) phenylacetamide; (6) 4-benzoxybenzenesulphonamide sodium salt (prepared from 4 - benzoxybenzenesulphonamide and sodium methylate in pyridine) is reacted with benzoyl chloride in ether and hydrolysed to yield N - (4 - hydroxybenzenesulphonyl) benzamide; (7) N - (4 - hydroxybenzenesulphonyl) furamide is prepared as in (6) but using furoyl chloride; (8) the sodium salt of 4-benzoxybenzenesulphonamide is reacted with phenylacetyl chloride in ether and the product hydrolysed to yield N-(4-hydroxyphenylsulphonyl) phenylacetamide; and (9) N - (4-hydroxybenzenesulphonyl) - 4 - chlorobenzamide is prepared as in (6) but using p-chlorobenzoyl chloride. |
| priorityDate | 1949-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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