http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-675611-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_14effe3850d2129f863b969dac4f1db8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-215 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-215 |
| filingDate | 1950-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1952-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-675611-A |
| titleOfInvention | Improvements in or relating to substituted piperazines |
| abstract | The invention comprises 1-dialkylcarbamyl-4-substituted piperazines of the general formula <FORM:0675611/IV (b)/1> in which R and R1 are hydrogen atoms or alkyl groups of 1 to 4 carbon atoms, R11 and R111 are hydrogen atoms or aliphatic groups and X is a sulphur atom or an imino group. The invention includes also the addition salts of the above compounds and the preparation of the compounds by reacting the corresponding 1-dialkylcarbamyl piperazines or an addition salt thereof with an alkali metal thiocyanate, an aliphatic isothiocyanate, a dialkyl-thiocarbamyl halide, cyanamide, a monoalkyl-cyanamide, a dialkyl-cyanamide or an S-alkyl isothiourea. When an alkali metal thiocyanate is one of the reagents the reaction may be carried out in aqueous solution or by fusion; reactions with an aliphatic isothiocyanate or a dialkylthiocarbamyl halide may be effected in the presence of an organic solvent, and those with cyanamide or S-alkyl isothiourea in either aqueous or alcoholic solution. In examples: (1) trans - 1 - diethylcarbamyl - 2,5 - dimethyl-4-guanylpiperazine acetate is made from trans-1 - diethylcarbamyl - 2,5 - dimethylpiperazine (I) and cyanamide; (2) 1-diethylcarbamyl-4-guanylpiperazine hemisulphate is made from 1-diethylcarbamylpiperazine (II) and S-methyl isothiourea; (3) 1-diethylcarbamyl-4-thiocarbamylpiperazine is made from (II) and potassium thiocyanate; (4) 1-diethylcarbamyl-4-ethyl-thiocarbamylpiperazine is made from (II) and ethyl isothiocyanate; (5) trans-1-diethylcarbamyl - 2,5 - dimethyl - 4 - thiocarbamylpiperazine is made from (I) and potassium thiocyanate; and (6) 1-diethylcarbamyl-4-allylthiocarbamylpiperazine from (II) and allyl isothiocyanate. Specification 631,685 is referred to. |
| priorityDate | 1949-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.