http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-656864-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d1845a3df7b600cb98c6ab12e7d28769 |
| filingDate | 1948-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1951-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-656864-A |
| titleOfInvention | Preparation of amino alcohol esters of disubstituted malonic acids |
| abstract | Dialkylmalonic acid alkyl dialkylaminoalkyl esters are prepared by treatment of a dialkylmalonic acid monoalkyl ester with a chloroalkyldialkylamine. The products have the formula <FORM:0656864/IV (b)/1> where R1 to R5 represent alkyl which may be substituted and R6 is alkylene. In the examples: (1) di-n-butylcyanacetic acid ethyl ester is hydrolysed to di-n-butylmalonic acid ethyl ester amide, which is treated with acid and sodium nitrite to give di-n-butylmalonic acid monoethyl ester, further reaction of which with b -chloroethyldiethylamine in presence of potassium ethoxide affords di-n-butylmalonic acid ethyl diethylaminoethyl ester; (2) diethylmalonic acid monoethyl ester is similarly treated with b -chloroethyldiethylamine to give the ethyl diethylaminoethyl diester. It is stated that other substituted malonic acid alkyl monoesters and alkyl dialkylaminoalkyl diesters may be prepared where R2 and R3 are di-n-propyl-, di-isobutyl-, di-n-amyl-, di-isoamyl-, and where R2 is isopropyl and R3 either ethyl or butyl. The Specification as open to inspection under Sect. 91 comprises the statement that the amine reactant may be the halide or sulphonate of an amino alcohol, which may be piperidine ethanol; in addition the groups R2 and R3 may be aralkyl or aryl, e.g. the compound dibenzylmalonic acid monoethyl ester may be prepared and used in the reaction. This subject-matter does not appear in the Specification as accepted. |
| priorityDate | 1947-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.