http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-639492-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5f93513445af12cb3a46226d54127826 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b8408ecf31234128b1a3af2a759ef692 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1b0c198757da18cf77dfbdcef00abb70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c4821c53e3f6cb4a43162d69f6bdad4d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-02 |
| filingDate | 1948-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1950-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-639492-A |
| titleOfInvention | A process for the manufacture of adenosine-5-triphosphate |
| abstract | Adenosine-51-triphosphate is manufactured by treating an adenosine-51-triaralkylpyrophosphate with a tertiary organic base, converting the resulting adenosine-51-diaralkylpyrophosphate into a metal salt, treating this with a diaralkyl halogenophosphonate and hydrogenolysing the resulting adenosine-51-tetraaralkyltriphosphate (which need not be isolated but should be freed as far as possible from contaminating matter with the aid of solvents) to remove the aralkyl groups. In an example, silver adenosine-51-benzylphosphate is treated with dibenzyl chlorophosphonate, the resulting mixture of crude adenosine-51-tribenzylpyrophosphate and silver chloride is heated with N-methylmorpholine in dimethylformamide, the solution is filtered and poured into ether, the resulting precipitate is dissolved in aqueous dimethylformamide, and the solution is neutralized with caustic soda solution, filtered and treated with silver nitrate solution to precipitate the silver salt of adenosine-51-dibenzylpyrophosphate, which is treated with dibenzyl chlorophosphorate in a mixture of phenol and acetonitrile, and a dioxane solution of the resulting tetraaralkyltriphosphate is hydrogenated at room temperature and atmospheric pressure in the presence of palladium oxide and palladized charcoal, the product being isolated as its barium salt. This is contaminated with barium adenosine-51-pyrophosphate and barium pyrophosphate, the former of which may be removed by reprecipitation of the barium salt at pH 4 and the latter by converting the product so obtained into its acridine salt and recrystallizing from water. Specification 621,094 is referred to. |
| priorityDate | 1948-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.