http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-601746-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2dbb2d7ecbd600cf89fbdd230f4a466c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-64 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-64 |
| filingDate | 1945-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1948-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-601746-A |
| titleOfInvention | Process for the preparation of sulphonic derivatives of guanidine |
| abstract | p-Aminobenzenesulphonylguanidine and its derivatives, of the general formula <FORM:0601746/IV(b)/1> (or its tautomeric form), wherein R1 represents hydrogen or an acyl residue and R2 and R3 each represent hydrogen or an alkyl, aryl or aralkyl residue, are manufactured by the action of ammonia or a primary or secondary amine on an N-p-amino- or -acylamino-benzenesul-phonyl-S-alkylisothiourea, followed, if desired, by removal of the acyl group, if present, by hydrolysis. In an example, N-p-aminobenzene-sulphonyl-S-methylisothiourea is heated with aqueous ammonia in a sealed vessel to produce p-aminobenzenesulphonylguanidine. Samples have been furnished under Sect. 2 (5) of: (A) N - p - aminobenzenesulphonyl - N1 - methylguanidine, prepared by heating N-p-aminobenzenesulphonyl - S - methylisothiourea with aqueous monomethylamine and hydrochloric acid in a closed vessel; (B) N-p-aminobenzenesulphonyl-N1-ethylguanidine, prepared by similarly reacting N-p-acetylaminobenzenesulphonyl-S-methylisothiourea with monoethylamine and hydrolysing the resulting N-p-acetylaminobenzenesulphonyl - N1 - ethylguanidine; (C) N-p-aminobenzenesulphonyl-N1-n-propylguanidine, prepared from n-propylamine as in (A); (D) N-p-aminobenzenesulphonyl-N1-cyclohexylguanidine, prepared similarly from cyclohexylamine; (E) N-p-aminobenzenesulphonyl-N1 - benzylguanidine, prepared from monobenzylamine as in (B); (F) N-p-aminobenzenesulphonyl - N1 - diethylguanidine, prepared similarly from diethylamine. N-p-Amino- or -acylamino-benzenesulphonyl-S-alkylisothioureas are obtained by condensing an S-alkylisothiourea with p-acetylaminobenzenesulphonyl chloride or by alkylation of a p-aminobenzenesulphonylthiourea with an alkyl iodide. The Specification as open to inspection under Sect. 91 comprises also the manufacture of other compounds of the general formula <FORM:0601746/IV(b)/2> (or the tautomeric form), wherein R1, R2, R3 R4, R5 and R6 represent hydrogen atoms or alkyl, aryl, aralkyl or acyl residues, and the use of N - p - aminobenzenesulphonyl - S - aralkyliso - thioureas as starting materials. This subject-matter does not appear in the Specification as accepted. |
| priorityDate | 1941-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.